IL11RA
| Gene Symbol | IL11RA |
|---|---|
| Entrez Gene | 3590 |
| Alt Symbol | CRSDA |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 11 receptor, alpha |
| Other Description | IL-11 receptor subunit alpha|IL-11R subunit alpha|interleukin-11 receptor alpha chain|interleukin-11 receptor subunit alpha |
| Swissprots | Q5VZ80 Q14626 Q7KYJ7 Q16542 |
| Accessions | AAB36491 AAS00093 EAW58422 EAW58423 EAW58424 EAW58425 Q14626 AI377039 AK075530 AK094689 BAG52913 AK292073 BAF84762 BC003110 AAH03110 BT009864 AAP88866 DA917660 DC424068 DQ892342 ABM83268 DQ895548 ABM86474 U32324 AAB36492 Z38102 CAA86224 Z46595 CAA86570 NM_001142784 NP_001136256 NR_052010 NM_004512 NM_147162 |
| Function | Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. {ECO:0000269|PubMed:21741611}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. {ECO:0000269|PubMed:11141475}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage |
IL-11Rα CRISPR/Cas9 KO Plasmid (h) - sc-402503 from Santa Cruz Biotechnology
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IL-11Rα HDR Plasmid (h) - sc-402503-HDR from Santa Cruz Biotechnology
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IL-11Rα Double Nickase Plasmid (h) - sc-402503-NIC from Santa Cruz Biotechnology
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IL-11Rα Double Nickase Plasmid (h2) - sc-402503-NIC-2 from Santa Cruz Biotechnology
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IL-11Rα CRISPR Activation Plasmid (h) - sc-402503-ACT from Santa Cruz Biotechnology
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IL-11Rα CRISPR Activation Plasmid (h2) - sc-402503-ACT-2 from Santa Cruz Biotechnology
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IL-11Rα Lentiviral Activation Particles (h) - sc-402503-LAC from Santa Cruz Biotechnology
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IL-11Rα Lentiviral Activation Particles (h2) - sc-402503-LAC-2 from Santa Cruz Biotechnology
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IL-11Rα siRNA (h) - sc-35647 from Santa Cruz Biotechnology
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IL-11Rα shRNA Plasmid (h) - sc-35647-SH from Santa Cruz Biotechnology
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IL-11Rα shRNA (h) Lentiviral Particles - sc-35647-V from Santa Cruz Biotechnology
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IL11RA RNAi - H00003590-R04 from Novus Biologicals
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IL11RA RNAi - H00003590-R03 from Novus Biologicals
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MISSION® esiRNA - EHU157431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10564 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10564 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03007 from Sigma-Aldrich
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IL11RA siRNA (Human) - CRH2400 from Cohesion Biosciences
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IL11RA - MBS8236799 from MyBioSource
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Human IL11RA siRNA - orb262902 from Biorbyt
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IL11RA shRNA Plasmid (Human) - CHH2400 from Cohesion Biosciences
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IL11RA miRNA 3'UTR clone - MiUTR3H-03758 from Creative biogene
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