MMP24
| Gene Symbol | MMP24 |
|---|---|
| Entrez Gene | 10893 |
| Alt Symbol | MMP-24, MMP25, MT-MMP 5, MT-MMP5, MT5-MMP, MT5MMP, MTMMP5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | matrix metallopeptidase 24 (membrane-inserted) |
| Other Description | matrix metalloproteinase 24 (membrane-inserted)|matrix metalloproteinase-24|membrane-type 5 matrix metalloproteinase|membrane-type matrix metalloproteinase 5|membrane-type-5 matrix metalloproteinase |
| Swissprots | Q9H440 Q9Y5R2 B7ZBG8 |
| Accessions | EAW76222 Q9Y5R2 AB021227 BAA82967 AF131284 AAD42962 BC047614 AAH47614 BC172450 AAI72450 DQ300264 ABC17785 R60687 XM_011528500 XP_011526802 NM_006690 NP_006681 |
| Function | Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). {ECO:0000250}. |
| Subcellular Location | Matrix metalloproteinase-24: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. {ECO:0000250}. |
| Tissue Specificity | Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas. {ECO:0000269|PubMed:10363975}. |
MT-MMP-5 (V-14) - sc-19061 from Santa Cruz Biotechnology
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MT-MMP-5 (D-15) - sc-20912 from Santa Cruz Biotechnology
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MT-MMP-5 (C-13) - sc-19062 from Santa Cruz Biotechnology
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MT-MMP-5 (H-50) - sc-25529 from Santa Cruz Biotechnology
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MT-MMP-5 (C-12) - sc-20913 from Santa Cruz Biotechnology
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Anti-MMP24 antibody - ab135564 from Abcam
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Anti-MMP24 antibody - ab39095 from Abcam
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Anti-MMP24 antibody - ab39137 from Abcam
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Anti-MMP24 antibody - ab39143 from Abcam
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Anti-MMP24 antibody - Aminoterminal end - ab39138 from Abcam
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Anti-MMP24 antibody - Aminoterminal end active enzyme - ab39695 from Abcam
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Anti-MMP24 antibody - Cytoplasmic domain - ab11647 from Abcam
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Anti-MMP24 Antibody (aa411-425) - LS-C3131 from LifeSpan Bioscience
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Anti-MMP24 Antibody - LS-C189440 from LifeSpan Bioscience
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Anti-MMP24 Antibody (Internal, AP) - LS-C220028 from LifeSpan Bioscience
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Anti-MMP24 Antibody (Internal, APC) - LS-C220029 from LifeSpan Bioscience
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Anti-MMP24 Antibody (Internal, PE) - LS-C220032 from LifeSpan Bioscience
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Anti-MMP24 Antibody (Internal, Biotin) - LS-C220031 from LifeSpan Bioscience
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Anti-MMP24 Antibody (Internal, Azide-free, HRP) - LS-C220033 from LifeSpan Bioscience
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Anti-MMP24 Antibody (Internal, FITC) - LS-C220034 from LifeSpan Bioscience
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Anti-MMP24 Antibody (Hinge) - LS-C209765 from LifeSpan Bioscience
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Anti-MMP24 Antibody (aa468-517) - LS-C111119 from LifeSpan Bioscience
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Anti-MMP24 Antibody - LS-C137245 from LifeSpan Bioscience
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Anti-MMP24 Antibody (aa396-425) - LS-C100451 from LifeSpan Bioscience
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Anti-MMP24 Antibody (aa429-642) - LS-C295320 from LifeSpan Bioscience
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