MMP24
| Gene Symbol | MMP24 |
|---|---|
| Entrez Gene | 10893 |
| Alt Symbol | MMP-24, MMP25, MT-MMP 5, MT-MMP5, MT5-MMP, MT5MMP, MTMMP5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | matrix metallopeptidase 24 (membrane-inserted) |
| Other Description | matrix metalloproteinase 24 (membrane-inserted)|matrix metalloproteinase-24|membrane-type 5 matrix metalloproteinase|membrane-type matrix metalloproteinase 5|membrane-type-5 matrix metalloproteinase |
| Swissprots | Q9H440 Q9Y5R2 B7ZBG8 |
| Accessions | EAW76222 Q9Y5R2 AB021227 BAA82967 AF131284 AAD42962 BC047614 AAH47614 BC172450 AAI72450 DQ300264 ABC17785 R60687 XM_011528500 XP_011526802 NM_006690 NP_006681 |
| Function | Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). {ECO:0000250}. |
| Subcellular Location | Matrix metalloproteinase-24: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. {ECO:0000250}. |
| Tissue Specificity | Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas. {ECO:0000269|PubMed:10363975}. |
Active human MMP24 protein fragment - ab157081 from Abcam
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MMP24 peptide - ab41124 from Abcam
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MMP24 peptide - ab41125 from Abcam
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MMP24 peptide - ab41126 from Abcam
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MMP24 peptide - ab41127 from Abcam
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MMP24 peptide - ab43116 from Abcam
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MMP24 Antibody Blocking Peptide - LS-E8130 from LifeSpan Bioscience
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MMP24 Antibody Blocking Peptide - LS-E17006 from LifeSpan Bioscience
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Recombinant Human MMP-24/MT5-MMP Protein - P4929 from Novus Biologicals
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MMP-24/MT5-MMP Peptide - P1813 from Novus Biologicals
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MMP24-Antibody-Center-Blocking-Peptide - BP6205a from Abgent, a WuXi AppTec company
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MMP24 Blocking Peptide - 33R-3551 from Fitzgerald
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Human MMP24 Protein - abx067964 from Abbexa
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MMP-24 - P4929 from Acris Antibodies
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Recombinant Human MMP24, Catalytic Domain, His-tagged - MMP24-610H from Creative Biomart
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Recombinant Matrix Metalloproteinase 24 (MMP24) - RPB894Hu01 from Uscn Life Science Inc.
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MT5-MMP, Catalytic Domain, His•Tag ® , Human, Recombinant, E. coli - PF117 from EMD Millipore
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Recombinant Matrix Metalloproteinase 24 (MMP24) - RPB894Hu01 from Cloud-clone
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MMP-24/MT5-MMP Protein - NBP2-14239PEP from Novus Biologicals
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MMP24 Peptide, Human - M34GP09603H from Creative Peptides
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MMP24 Recombinant Protein (OPCD05337) - OPCD05337 from Aviva Systems Biology
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Matrix Metalloproteinase 24, Recombinant Protein - MBS2031459 from MyBioSource
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