MMP24
| Gene Symbol | MMP24 |
|---|---|
| Entrez Gene | 10893 |
| Alt Symbol | MMP-24, MMP25, MT-MMP 5, MT-MMP5, MT5-MMP, MT5MMP, MTMMP5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | matrix metallopeptidase 24 (membrane-inserted) |
| Other Description | matrix metalloproteinase 24 (membrane-inserted)|matrix metalloproteinase-24|membrane-type 5 matrix metalloproteinase|membrane-type matrix metalloproteinase 5|membrane-type-5 matrix metalloproteinase |
| Swissprots | Q9H440 Q9Y5R2 B7ZBG8 |
| Accessions | EAW76222 Q9Y5R2 AB021227 BAA82967 AF131284 AAD42962 BC047614 AAH47614 BC172450 AAI72450 DQ300264 ABC17785 R60687 XM_011528500 XP_011526802 NM_006690 NP_006681 |
| Function | Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). {ECO:0000250}. |
| Subcellular Location | Matrix metalloproteinase-24: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. {ECO:0000250}. |
| Tissue Specificity | Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas. {ECO:0000269|PubMed:10363975}. |
MT-MMP-5 CRISPR/Cas9 KO Plasmid (h) - sc-405475 from Santa Cruz Biotechnology
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MT-MMP-5 HDR Plasmid (h) - sc-405475-HDR from Santa Cruz Biotechnology
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MT-MMP-5 Double Nickase Plasmid (h) - sc-405475-NIC from Santa Cruz Biotechnology
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MT-MMP-5 Double Nickase Plasmid (h2) - sc-405475-NIC-2 from Santa Cruz Biotechnology
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MT-MMP-5 CRISPR Activation Plasmid (h) - sc-405475-ACT from Santa Cruz Biotechnology
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MT-MMP-5 CRISPR Activation Plasmid (h2) - sc-405475-ACT-2 from Santa Cruz Biotechnology
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MT-MMP-5 Lentiviral Activation Particles (h) - sc-405475-LAC from Santa Cruz Biotechnology
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MT-MMP-5 Lentiviral Activation Particles (h2) - sc-405475-LAC-2 from Santa Cruz Biotechnology
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MT-MMP-5 siRNA (h) - sc-41571 from Santa Cruz Biotechnology
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MT-MMP-5 shRNA Plasmid (h) - sc-41571-SH from Santa Cruz Biotechnology
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MT-MMP-5 shRNA (h) Lentiviral Particles - sc-41571-V from Santa Cruz Biotechnology
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MMP-24/MT5-MMP RNAi - H00010893-R01 from Novus Biologicals
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MISSION® esiRNA - EHU007181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14433 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14433 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11488 from Sigma-Aldrich
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MMP24 siRNA (Human) - CRH7423 from Cohesion Biosciences
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shRNA set against Human MMP24 (NM_006690.3) - SHH343044 from Creative biogene
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shRNA set against Human MMP24(NM_006690.3) - SHH193853 from Creative biogene
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Human MMP24 siRNA - orb267925 from Biorbyt
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MMP24 shRNA Plasmid (Human) - CHH7423 from Cohesion Biosciences
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MMP24 miRNA 3'UTR clone - MiUTR1H-06355 from Creative biogene
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