| Gene Symbol |
MMP24
|
| Entrez Gene |
10893
|
| Alt Symbol |
MMP-24, MMP25, MT-MMP 5, MT-MMP5, MT5-MMP, MT5MMP, MTMMP5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
matrix metallopeptidase 24 (membrane-inserted)
|
| Other Description |
matrix metalloproteinase 24 (membrane-inserted)|matrix metalloproteinase-24|membrane-type 5 matrix metalloproteinase|membrane-type matrix metalloproteinase 5|membrane-type-5 matrix metalloproteinase
|
| Swissprots |
Q9H440 Q9Y5R2 B7ZBG8
|
| Accessions |
EAW76222 Q9Y5R2 AB021227 BAA82967 AF131284 AAD42962 BC047614 AAH47614 BC172450 AAI72450 DQ300264 ABC17785 R60687 XM_011528500 XP_011526802 NM_006690 NP_006681
|
| Function |
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Matrix metalloproteinase-24: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas. {ECO:0000269|PubMed:10363975}.
|