Gene Symbol | ZRANB1 |
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Entrez Gene | 54764 |
Alt Symbol | TRABID |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger, RAN-binding domain containing 1 |
Other Description | TRAF-binding domain-containing protein|TRAF-binding protein domain|hTrabid|ubiquitin thioesterase ZRANB1|zinc finger Ran-binding domain-containing protein 1 |
Swissprots | Q5SQP6 Q69YK3 D3DRF4 B4DZ98 Q9UGI0 |
Accessions | EAW49252 EAW49253 Q9UGI0 AJ252060 CAB64449 AK302810 BAG64010 AK307386 AL832925 CAH10620 BC048281 BC152728 AAI52729 HG503330 XM_005269925 XP_005269982 XM_005269926 XP_005269983 XM_006717907 XP_006717970 XM_011539887 XP_011538189 NM_017580 NP_060050 |
Function | Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling. {ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22157957, ECO:0000269|PubMed:23827681}. |
Subcellular Location | Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11463333}. |
TRABID (F-1) - sc-374377 from Santa Cruz Biotechnology
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TRABID (C-13) - sc-135536 from Santa Cruz Biotechnology
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TRABID (E-13) - sc-135537 from Santa Cruz Biotechnology
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Anti-ZRANB1 antibody - ab103417 from Abcam
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Anti-ZRANB1 antibody - ab82132 from Abcam
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Anti-ZRANB1 / TRABID Antibody (aa665-692) - LS-C160970 from LifeSpan Bioscience
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Anti-ZRANB1 / TRABID Antibody (aa672-701, AP) - LS-C218550 from LifeSpan Bioscience
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Anti-ZRANB1 / TRABID Antibody (aa672-701, APC) - LS-C218552 from LifeSpan Bioscience
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Anti-ZRANB1 / TRABID Antibody (aa672-701, Biotin) - LS-C218553 from LifeSpan Bioscience
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Anti-ZRANB1 / TRABID Antibody (aa672-701, FITC) - LS-C218554 from LifeSpan Bioscience
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Anti-ZRANB1 / TRABID Antibody (aa672-701, Azide-free, HRP) - LS-C218555 from LifeSpan Bioscience
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Anti-ZRANB1 / TRABID Antibody (aa672-701, PE) - LS-C218556 from LifeSpan Bioscience
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Anti-ZRANB1 / TRABID Antibody (aa665-692) - LS-C326743 from LifeSpan Bioscience
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Anti-ZRANB1 / TRABID Antibody (aa682-695) - LS-C87318 from LifeSpan Bioscience
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Anti-ZRANB1 / TRABID Antibody (aa601-650) - LS-C116833 from LifeSpan Bioscience
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ZRANB1/Trabid Antibody - NBP1-86918 from Novus Biologicals
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ZRANB1/Trabid Antibody - NBP1-86917 from Novus Biologicals
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ZRANB1/Trabid Antibody - NBP1-86916 from Novus Biologicals
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ZRANB1/Trabid Antibody - NBP1-01469 from Novus Biologicals
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ZRANB1/Trabid Antibody - NBP1-31911 from Novus Biologicals
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Anti-ZRANB1 antibody produced in rabbit - HPA029241 from Sigma-Aldrich
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Anti-TRABID/ZRANB1 antibody produced in goat - SAB2501055 from Sigma-Aldrich
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Anti-ZRANB1 antibody produced in rabbit - HPA029239 from Sigma-Aldrich
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Anti-ZRANB1 antibody produced in rabbit - HPA029240 from Sigma-Aldrich
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ZRANB1 antibody - C-terminal region (ARP59341_P050) - ARP59341_P050 from Aviva Systems Biology
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