| Gene Symbol |
ZRANB1
|
| Entrez Gene |
54764
|
| Alt Symbol |
TRABID
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, RAN-binding domain containing 1
|
| Other Description |
TRAF-binding domain-containing protein|TRAF-binding protein domain|hTrabid|ubiquitin thioesterase ZRANB1|zinc finger Ran-binding domain-containing protein 1
|
| Swissprots |
Q5SQP6 Q69YK3 D3DRF4 B4DZ98 Q9UGI0
|
| Accessions |
EAW49252 EAW49253 Q9UGI0 AJ252060 CAB64449 AK302810 BAG64010 AK307386 AL832925 CAH10620 BC048281 BC152728 AAI52729 HG503330 XM_005269925 XP_005269982 XM_005269926 XP_005269983 XM_006717907 XP_006717970 XM_011539887 XP_011538189 NM_017580 NP_060050
|
| Function |
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling. {ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22157957, ECO:0000269|PubMed:23827681}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Enriched in punctate localization in the cytoplasm.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:11463333}.
|