| Gene Symbol |
RNF7
|
| Entrez Gene |
9616
|
| Alt Symbol |
CKBBP1, ROC2, SAG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 7
|
| Other Description |
CKII beta-binding protein 1|RING-box protein 2|rbx2|regulator of cullins 2|sensitive to apoptosis gene protein|sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2|zinc RING finger protein SAG
|
| Swissprots |
A8MTB5 Q9BXN8 D3DNF8 A8K1H9 Q9Y5M7 D3DNF7 C9JYL3 Q9UBF6
|
| Accessions |
EAW78991 EAW78992 EAW78993 EAW78994 EAW78995 EAW78996 Q9UBF6 AF092878 AAD25962 AF142060 AAD30147 AF164679 AAD55984 AF312226 AAK37450 AK289894 BAF82583 AK311982 BAG34921 AW150174 BC005966 AAH05966 BC008627 AAH08627 BF439211 BG715867 BG716023 BG720797 BG742338 BT007348 AAP36012 BU959624 CA415974 DB272382 DQ891759 ABM82685 DQ894943 ABM85869 NM_001201370 NP_001188299 NM_014245 NP_055060 NM_183237 NP_899060 NR_037702 NR_037703 NM_183063
|
| Function |
Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. {ECO:0000269|PubMed:10851089}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10082581}. Nucleus {ECO:0000269|PubMed:10082581}.
|
| Tissue Specificity |
Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung. {ECO:0000269|PubMed:10512750}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|
![Western Blot: RNF7 Overexpression Lysate (Adult Normal) [NBL1-15459] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RNF7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8194_RNF7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15459-img0002.jpg)