RNF7
| Gene Symbol | RNF7 |
|---|---|
| Entrez Gene | 9616 |
| Alt Symbol | CKBBP1, ROC2, SAG |
| Species | Human |
| Gene Type | protein-coding |
| Description | ring finger protein 7 |
| Other Description | CKII beta-binding protein 1|RING-box protein 2|rbx2|regulator of cullins 2|sensitive to apoptosis gene protein|sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2|zinc RING finger protein SAG |
| Swissprots | A8MTB5 Q9BXN8 D3DNF8 A8K1H9 Q9Y5M7 D3DNF7 C9JYL3 Q9UBF6 |
| Accessions | EAW78991 EAW78992 EAW78993 EAW78994 EAW78995 EAW78996 Q9UBF6 AF092878 AAD25962 AF142060 AAD30147 AF164679 AAD55984 AF312226 AAK37450 AK289894 BAF82583 AK311982 BAG34921 AW150174 BC005966 AAH05966 BC008627 AAH08627 BF439211 BG715867 BG716023 BG720797 BG742338 BT007348 AAP36012 BU959624 CA415974 DB272382 DQ891759 ABM82685 DQ894943 ABM85869 NM_001201370 NP_001188299 NM_014245 NP_055060 NM_183237 NP_899060 NR_037702 NR_037703 NM_183063 |
| Function | Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. {ECO:0000269|PubMed:10851089}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10082581}. Nucleus {ECO:0000269|PubMed:10082581}. |
| Tissue Specificity | Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung. {ECO:0000269|PubMed:10512750}. |
| Top Pathways | Ubiquitin mediated proteolysis |
Rbx2 CRISPR/Cas9 KO Plasmid (h) - sc-417138 from Santa Cruz Biotechnology
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Rbx2 HDR Plasmid (h) - sc-417138-HDR from Santa Cruz Biotechnology
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Rbx2 Double Nickase Plasmid (h) - sc-417138-NIC from Santa Cruz Biotechnology
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Rbx2 Double Nickase Plasmid (h2) - sc-417138-NIC-2 from Santa Cruz Biotechnology
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Rbx2 CRISPR Activation Plasmid (h) - sc-417138-ACT from Santa Cruz Biotechnology
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Rbx2 CRISPR Activation Plasmid (h2) - sc-417138-ACT-2 from Santa Cruz Biotechnology
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Rbx2 Lentiviral Activation Particles (h) - sc-417138-LAC from Santa Cruz Biotechnology
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Rbx2 Lentiviral Activation Particles (h2) - sc-417138-LAC-2 from Santa Cruz Biotechnology
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Rbx2 siRNA (h) - sc-44073 from Santa Cruz Biotechnology
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Rbx2 shRNA Plasmid (h) - sc-44073-SH from Santa Cruz Biotechnology
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Rbx2 shRNA (h) Lentiviral Particles - sc-44073-V from Santa Cruz Biotechnology
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RNF7 RNAi - H00009616-R03 from Novus Biologicals
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RNF7 RNAi - H00009616-R01 from Novus Biologicals
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RNF7 RNAi - H00009616-R02 from Novus Biologicals
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MISSION® esiRNA - EHU100351 from Sigma-Aldrich
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MISSION® esiRNA - EHU094071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18443 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18443 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08897 from Sigma-Aldrich
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RNF7 siRNA (Human) - CRH6398 from Cohesion Biosciences
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RNF7 - MBS8237098 from MyBioSource
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shRNA set against Human RNF7 (NM_014245.4) - SHH397420 from Creative biogene
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shRNA set against Human RNF7(NM_183237.2) - SHR188464 from Creative biogene
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Human RNF7 siRNA - orb266900 from Biorbyt
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RNF7 shRNA Plasmid (Human) - CHH6398 from Cohesion Biosciences
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