RNF7

Gene Symbol	RNF7
Entrez Gene	9616
Alt Symbol	CKBBP1, ROC2, SAG
Species	Human
Gene Type	protein-coding
Description	ring finger protein 7
Other Description	CKII beta-binding protein 1|RING-box protein 2|rbx2|regulator of cullins 2|sensitive to apoptosis gene protein|sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2|zinc RING finger protein SAG
Swissprots	A8MTB5 Q9BXN8 D3DNF8 A8K1H9 Q9Y5M7 D3DNF7 C9JYL3 Q9UBF6
Accessions	EAW78991 EAW78992 EAW78993 EAW78994 EAW78995 EAW78996 Q9UBF6 AF092878 AAD25962 AF142060 AAD30147 AF164679 AAD55984 AF312226 AAK37450 AK289894 BAF82583 AK311982 BAG34921 AW150174 BC005966 AAH05966 BC008627 AAH08627 BF439211 BG715867 BG716023 BG720797 BG742338 BT007348 AAP36012 BU959624 CA415974 DB272382 DQ891759 ABM82685 DQ894943 ABM85869 NM_001201370 NP_001188299 NM_014245 NP_055060 NM_183237 NP_899060 NR_037702 NR_037703 NM_183063
Function	Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. {ECO:0000269|PubMed:10851089}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10082581}. Nucleus {ECO:0000269|PubMed:10082581}.
Tissue Specificity	Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung. {ECO:0000269|PubMed:10512750}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF7 full length protein - ab132407 from Abcam Category Protein Source Wheat germ Species Human

Human RNF7 full length protein - ab171587 from Abcam Category Protein Source E. coli Species Human

Human RNF7 peptide - ab23002 from Abcam Category Peptide Species Human

RNF7 Antibody Blocking Peptide - LS-E27246 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RNF7 Protein - H00009616-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RNF7 Protein - NBP2-23442 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

RNF7 blocking peptide - GTX88232-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

RNF7/SAG/ROC2 blocking peptide - GTX89838-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Human RNF7 protein - orb191292 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human RNF7 protein - orb245975 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

RNF7 protein (His tag) - 80R-2992 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

RNF7 Peptide - AC21-2067-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RNF7 (1-113, His-tag) - AR51110PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

RNF7 (1-113, His-tag) - AR51110PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

RNF7 - H00009616-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF7 - H00009616-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF7, 1-113aa, Human, His tag, E.coli - 01-P2286 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

RNF7 Peptide - 42-275P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

SAG fusion protein - Ag16903 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SAG fusion protein - ag2553 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RNF7, 1-113aa, Human, His tag, E.coli - GWB-ATG469 from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Species Human

Recombinant Human RNF7, His-tagged - RNF7-2286H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant human RING-box protein 2 - CSB-YP019897HU CSB-BP019897HU CSB-MP019897HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human RING-box protein 2 - CSB-EP019897HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Human RING-box protein 2(RNF7) - CSB-YP880060HU CSB-EP880060HU CSB-BP880060HU CSB-MP880060HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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