| Gene Symbol | AKT1S1 |
|---|---|
| Entrez Gene | 84335 |
| Alt Symbol | Lobe, PRAS40 |
| Species | Human |
| Gene Type | protein-coding |
| Description | AKT1 substrate 1 (proline-rich) |
| Other Description | 40 kDa proline-rich AKT substrate|proline-rich AKT1 substrate 1 |
| Swissprots | A8MTQ1 Q96B36 Q9BWR5 Q96BI4 J3KPM3 B2RE93 Q96NG2 Q96IK7 |
| Accessions | EAW52568 EAW52569 EAW52570 EAW52571 Q96B36 AK055511 BAB70937 AK092610 BAG52583 AK123687 AK226004 AK316603 BAG38190 BC000031 AAH00031 BC007416 AAH07416 BC015562 AAH15562 BC016043 AAH16043 BC022241 BC051844 AAH51844 DA005259 DA476468 DA542314 DA848626 NM_001098632 NP_001092102 NM_001098633 NP_001092103 NM_001278159 NP_001265088 NM_001278160 NP_001265089 NM_032375 NP_115751 |
| Function | Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phospho |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Note=Found in the cytosolic fraction of the brain. {ECO:0000250}. |
| Tissue Specificity | Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A-549 and HeLa) than in normal cell lines (e.g. HEK293). {ECO:0000269|PubMed:12524439, ECO:0000269|PubMed:16174443}. |
| Top Pathways | AMPK signaling pathway, mTOR signaling pathway |