AKT1S1

Gene Symbol	AKT1S1
Entrez Gene	84335
Alt Symbol	Lobe, PRAS40
Species	Human
Gene Type	protein-coding
Description	AKT1 substrate 1 (proline-rich)
Other Description	40 kDa proline-rich AKT substrate|proline-rich AKT1 substrate 1
Swissprots	A8MTQ1 Q96B36 Q9BWR5 Q96BI4 J3KPM3 B2RE93 Q96NG2 Q96IK7
Accessions	EAW52568 EAW52569 EAW52570 EAW52571 Q96B36 AK055511 BAB70937 AK092610 BAG52583 AK123687 AK226004 AK316603 BAG38190 BC000031 AAH00031 BC007416 AAH07416 BC015562 AAH15562 BC016043 AAH16043 BC022241 BC051844 AAH51844 DA005259 DA476468 DA542314 DA848626 NM_001098632 NP_001092102 NM_001098633 NP_001092103 NM_001278159 NP_001265088 NM_001278160 NP_001265089 NM_032375 NP_115751
Function	Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phospho
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Note=Found in the cytosolic fraction of the brain. {ECO:0000250}.
Tissue Specificity	Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A-549 and HeLa) than in normal cell lines (e.g. HEK293). {ECO:0000269|PubMed:12524439, ECO:0000269|PubMed:16174443}.
Top Pathways	AMPK signaling pathway, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AKT1S1 / PRAS40 Antibody Blocking Peptide - LS-E3135 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AKT1S1 / PRAS40 Antibody Blocking Peptide - LS-E31452 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

AKT1S1 / PRAS40 Antibody Blocking Peptide - LS-E17391 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AKT1S1-Antibody-C-term-Blocking-Peptide - BP14275b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AKT1S1 Blocking Peptide - 33R-4654 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AKT1S1 Peptide - 7391P from ProSci Category Peptide Species Human

PRAS40 fusion protein - Ag15355 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human AKT1 Substrate 1 (Proline-rich) - AKT1S1-2377H from Creative Biomart Category Protein Source E. coli.

Recombinant Human AKT1 Substrate 1 (proline-rich), His-tagged And Myc-tagged - AKT1S1-1854H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human AKT1S1, GST-tagged - AKT1S1-1934H from Creative Biomart Category Protein Source E.coli Species Human

PRAS40 (P240) Peptide - BS1504P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-PRAS40 (T246) Peptide - BS4288P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Proline-rich AKT1 substrate 1(AKT1S1) - CSB-YP836185HU CSB-EP836185HU CSB-BP836185HU CSB-MP836185HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PRAS40 (pT246) Blocking Peptide - CBP4332 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine

PRAS40 Blocking Peptide - CBP4333 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine

PRAS40 (pT246) Blocking Peptide - abx161543 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine

PRAS40 Blocking Peptide - abx161544 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine

AKT1S1 / PRAS40 (transcript variant 1) - TP300919 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

AKT1S1 / PRAS40 (transcript variant 2) - TP311995 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

AKT1S1 / PRAS40 (transcript variant 3) - TP312216 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Proline-rich AKT1 substrate 1 (AKT1S1), Recombinant Protein - MBS1362815 from MyBioSource Category Protein Prices $1,005.00, $1,005.00, $1,235.00, $1,235.00, $1,545.00, $1,545.00, $2,010.00, $2,010.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human AKT1S1 (aa 2-256) His-Tagged myc-Tagged - CRP004A from Cell Science Prices $195.00 Sizes 25 µg Source E. coli Species Human

Recombinant Human AKT1S1 protein, MYC/DDK-tagged - AKT1S1-25H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human AKT1S1 protein, MYC/DDK-tagged - AKT1S1-26H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human AKT1S1 protein, MYC/DDK-tagged - AKT1S1-27H from Creative Biomart Category Protein Source HEK293 Species Human

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