SRA1

Gene Symbol SRA1
Entrez Gene 10011
Alt Symbol SRA, SRAP, STRAA1, pp7684
Species Human
Gene Type protein-coding
Description steroid receptor RNA activator 1
Other Description steroid receptor RNA activator 1 (complexes with NCOA1)|steroid receptor RNA activator protein|steroid receptor coactivator
Swissprots Q9HD15 Q9HD13 Q8IXM1 Q6NVU9 Q9HD14
Accessions EAW62051 EAW62052 Q9HD15 AF092038 AF293024 AAG02114 AF293025 AAG02115 AF293026 AAG02116 AF318361 AAL55868 AI140060 AK024640 AK054960 BAG51445 BC040043 AAH40043 BC067895 BC152788 AAI52789 BC156760 AAI56761 BQ052761 BU553214 CX165918 DA311407 DQ286291 NM_001035235 NP_001030312 NM_001253764 NP_001240693 NR_045586 NR_045587
Function Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. {ECO:0000269|PubMed:10199399, ECO:0000269|PubMed:12943696, ECO:0000269|PubMed:14517287, ECO:0000269|PubMed:15147866, ECO:0000269|PubMed:15351741}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12565891}. Cytoplasm {ECO:0000269|PubMed:12565891}.
Tissue Specificity Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up- regulated in human tumors of the breast, ovary, and uterus. {ECO:0000269|PubMed:10199399, ECO:0000269|PubMed:12565891, ECO:0000269|PubMed:14517287}.

SRA (D-8) - sc-271948 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SRA (D-8): sc-271948. Western blot analysis of SRA expression in non-transfected: sc-117752 (A) and mouse SRA transfected: sc-123773 (B) 293T whole cell lysates.

SRA (7H1G1) - sc-56777 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SRA (7H1G1): sc-56777. Western blot analysis of human recombinant SRA protein (A) and SRA expression in human ovary cancer tissue extract (B).

SRA (C-5) - sc-271377 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SRA (C-5): sc-271377. Western blot analysis of SRA expression in non-transfected: sc-117752 (A) and mouse SRA transfected: sc-123773 (B) 293T whole cell lysates.

SRA (FL-220) - sc-32913 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SRA (FL-220): sc-32913. Western blot analysis of SRA expression in NIH/3T3 whole cell lysate.

SRA (N-20) - sc-26839 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SRA (N-20): sc-26839. Western blot analysis of SRA expression in non-transfected: sc-117752 (A) and mouse SRA transfected: sc-123773 (B) 293T whole cell lysates.

SRA (A-18) - sc-26840 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SRA (A-18): sc-26840. Western blot analysis of SRA expression in rat skeletal muscle tissue extract.

Anti-SRA1 antibody - ab72552 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling SRA1 with ab72552 at 1/200 (1µg/ml). Detection: DAB.

Anti-SRA1 antibody - ab72407 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SRA1 antibody (ab72407) at 0.1 µg/mlLane 1 : Whole cell lysate from Hela cells at 20 µgLane 2 : Whole cell lysate from Hela cells at 4 µgLane 3 : Whole cell lysate from MCF-7 cells at 20 µgLane 4 : Whole cell lysate from 293T cells at 20 µgdeveloped using the ECL technique

Anti-SRA1 antibody - ab84388 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84388, at a 1/100 dilution, staining SRA1 in formalin fixed, paraffin embedded human metastatic lymph node tissue by Immunohistochemistry. Detection: DAB staining.

Anti-SRA1 antibody - ab118676 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SRA1 antibody (ab118676) at 1 µg/ml + HT1080 cell lysate at 10 µg

Anti-SRA1 antibody [1D4H8] - ab66378 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1D4H8
All lanes : Anti-SRA1 antibody [1D4H8] (ab66378) at 1/500 dilutionLane 1 : truncated SRA recombinant proteinLane 2 : ovary carcinoma tissue lysateLane 3 : A431 cell lysate

Anti-SRA1 antibody [7H1G1] - ab36625 from Abcam

Prices $388.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7H1G1
ICC/IF image of ab36625 stained HeLa cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab36625 at 1/200 dilution overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- mouse (ab96879) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-SRA1 antibody [EPR11776] - ab183725 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11776
Anti-SRA1 antibody [EPR11776] (ab183725) at 1/2000 dilution + Human fetal liver lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-SRA1 / SRA Antibody - LS-C48702 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SRA1 / SRA Antibody (aa50-100) - LS-C91769 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-SRA1 / SRA Antibody (aa193-222, Biotin) - LS-C270285 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRA1 / SRA Antibody (aa193-222, AP) - LS-C270283 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRA1 / SRA Antibody (aa193-222, APC) - LS-C270284 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRA1 / SRA Antibody (aa193-222, Azide-free, HRP) - LS-C270287 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRA1 / SRA Antibody (aa193-222, FITC) - LS-C270286 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRA1 / SRA Antibody (aa193-222, PE) - LS-C270289 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRA1 / SRA Antibody (C-Terminus) - LS-C287607 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SRA1 / SRA Antibody (aa192-222) - LS-C325365 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRA1 / SRA Antibody (aa92-141) - LS-C145660 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SRA1 antibody LS-C145660 Western blot of HT1080 Cell lysate. Antibody concentration 1 ug/ml.

Anti-SRA1 / SRA Antibody (N-Terminus) - LS-C116085 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SRA1 antibody LS-C116085 Western blot of Mouse Small Intestine lysate.
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