| Gene Symbol |
SRA1
|
| Entrez Gene |
10011
|
| Alt Symbol |
SRA, SRAP, STRAA1, pp7684
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
steroid receptor RNA activator 1
|
| Other Description |
steroid receptor RNA activator 1 (complexes with NCOA1)|steroid receptor RNA activator protein|steroid receptor coactivator
|
| Swissprots |
Q9HD15 Q9HD13 Q8IXM1 Q6NVU9 Q9HD14
|
| Accessions |
EAW62051 EAW62052 Q9HD15 AF092038 AF293024 AAG02114 AF293025 AAG02115 AF293026 AAG02116 AF318361 AAL55868 AI140060 AK024640 AK054960 BAG51445 BC040043 AAH40043 BC067895 BC152788 AAI52789 BC156760 AAI56761 BQ052761 BU553214 CX165918 DA311407 DQ286291 NM_001035235 NP_001030312 NM_001253764 NP_001240693 NR_045586 NR_045587
|
| Function |
Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. {ECO:0000269|PubMed:10199399, ECO:0000269|PubMed:12943696, ECO:0000269|PubMed:14517287, ECO:0000269|PubMed:15147866, ECO:0000269|PubMed:15351741}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12565891}. Cytoplasm {ECO:0000269|PubMed:12565891}.
|
| Tissue Specificity |
Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up- regulated in human tumors of the breast, ovary, and uterus. {ECO:0000269|PubMed:10199399, ECO:0000269|PubMed:12565891, ECO:0000269|PubMed:14517287}.
|