SLC4A8

Gene Symbol	SLC4A8
Entrez Gene	9498
Alt Symbol	NBC3, NDCBE
Species	Human
Gene Type	protein-coding
Description	solute carrier family 4, sodium bicarbonate cotransporter, member 8
Other Description	electroneutral Na(+)-driven Cl-HCO3 exchanger\|electroneutral sodium bicarbonate exchanger 1\|k-NBC3
Swissprots	Q8TC60 Q8N3U2 E7EML0 Q2Y0W8 Q9UKX8 A0MMZ1 O95233 B4DHY0 Q004B4 F5H7F5 O94843 F5GZ31
Accessions	EAW58191 EAW58192 EAW58193 Q2Y0W8 AB018282 BAA34459 AF069512 AAC82380 AF107099 AAD52981 AI377345 AK056222 AK093005 AK093357 AK124576 AK128321 AK295315 BAG58292 AK299545 BAG61491 AK310017 AL137310 AL831915 CAD38576 AW118662 BC025994 AAH25994 DA521806 DB220099 DQ063579 AAY79176 DQ975204 ABJ09587 DQ996398 ABJ91577 DQ996537 ABJ91576 EU637925 XM_006719700 XP_006719763 XM_011539010 XP_011537312 XM_011539011 XP_011537313 XM_011539012 XP_011537314 XM_011539013 XP_011537315 XM_011539014 XP_011537316 NM_001039960 NP_001035049 NM_001258401 NP_001245330 NM_001258402 NP_001245331 NM_001258403 NP_001245332 NM_001267615 NP_001254544 NR_047672 NM_004858
Function	Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. {ECO:0000269\|PubMed:10362779, ECO:0000269\|PubMed:11133997}.
Subcellular Location	Membrane {ECO:0000269\|PubMed:17715183}; Multi-pass membrane protein {ECO:0000269\|PubMed:17715183}.
Tissue Specificity	Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. {ECO:0000269\|PubMed:10362779, ECO:0000269\|PubMed:11133997, ECO:0000269\|PubMed:17715183}.

SLC4A8 (V-14) - sc-169346 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

SLC4A8 (H-48) - sc-292031 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

SLC4A8 (H-48): sc-292031. Western blot analysis of SLC4A8 expression in human salivary gland tissue extract.

SLC4A8 (LX-2) - sc-100672 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

SLC4A8 (LX-2): sc-100672. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human salivary gland tissue showing membrane localization.

Anti-SLC4A8 antibody - ab125910 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SLC4A8 antibody (ab125910) at 1/1000 dilution + Human U87-M6 whole cell lysate at 30 µg

Anti-SLC4A8 antibody - ab199602 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLC4A8 antibody (ab199602) at 1/1000 dilution + MCF-7 cell lysate at 35 µgSecondaryGoat anti-rabbit IgG H&L(HRP) at 1/5000 dilution

Anti-SLC4A8 antibody - ab56708 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

SLC4A8 antibody (ab56708) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human salivary gland.

Anti-SLC4A8 / NBC Antibody (N-Terminus) - LS-C155211 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Sample (30 ug of whole cell lysate) A: U87-MG 7.5% SDS PAGE SLC4A8 antibody diluted at 1:1000

Anti-SLC4A8 / NBC Antibody (clone 6E11) - LS-C105083 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	6E11

Anti-SLC4A8 / NBC Antibody (N-Terminus) - LS-C37468 from LifeSpan Bioscience

Prices	$445.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SLC4A8 / NBC Antibody (aa266-278) - LS-C112959 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-SLC4A8 / NBC Antibody (aa187-287, Azide-free) - LS-C330655 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

SLC4A8 Antibody - NBP1-92407 from Novus Biologicals

Host	Rabbit
Clonality	Polyclonal

Western Blot: SLC4A8 Antibody [NBP1-92407] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

SLC4A8 Antibody (1G10) - H00009498-M05 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1G10

Western Blot: SLC4A8 Antibody (1G10) [H00009498-M05] - Analysis of SLC4A8 expression in NIH/3T3 (Cat # L018V1).

SLC4A8 Antibody (6E11) - H00009498-M04 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	6E11

Immunohistochemistry-Paraffin: SLC4A8 Antibody (6E11) [H00009498-M04] - Analysis of monoclonal antibody to SLC4A8 on formalin-fixed paraffin-embedded human salivary gland. Antibody concentration 3 ug/ml

SLC4A8 Antibody - NBP1-52161 from Novus Biologicals

Prices	$229.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

SLC4A8 Antibody - NBP2-20395 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: SLC4A8 Antibody [NBP2-20395] - Sample (30 ug of whole cell lysate) A: U87-MG 7. 5% SDS PAGE gel, diluted at 1:1000.

Monoclonal Anti-SLC4A8 antibody produced in mouse - SAB1404728 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1G10

<B>Immunoblotting</B><BR/>Monoclonal Anti-SLC4A8: <B>Cat. No. SAB1404728</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~77.1 kDa using HeLa lysate.

Monoclonal Anti-SLC4A8 antibody produced in mouse - WH0009498M4 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	6E11

<B>Immunoblotting</B><BR/>Monoclonal Anti-SLC4A8, <B>Cat. No. WH0009498M4</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37.11 kDa using immunogen protein lysate.

Anti-SLC4A8 antibody produced in rabbit - HPA046665 from Sigma-Aldrich

Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-SLC4A8: <B>Cat. No. HPA046665</B>: Immunohistochemical staining of human liver shows distinct positivity of bile canaliculi.

SLC4A8-Antibody-monoclonal-M05 - AT3929a from Abgent, a WuXi AppTec company

Prices	$315.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1G10

Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .

SLC4A8-Antibody-monoclonal-M04 - AT3928a from Abgent, a WuXi AppTec company

Prices	$315.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	6E12

SLC4A810-Antibody - AP50773 from Abgent, a WuXi AppTec company

Prices	$295.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of lysate from MCF-7 cell line,using SLC4A8/10 Antibody(AP50773). AP50773 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.

SLC4A8-Antibody-internal-region - AF3163a from Abgent, a WuXi AppTec company

Prices	$325.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

SLC4A8 Antibody (OAAB18566) - OAAB18566 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

SLC4A8 Antibody (OAAF04323) - OAAF04323 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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