SLC4A8

Gene Symbol SLC4A8
Entrez Gene 9498
Alt Symbol NBC3, NDCBE
Species Human
Gene Type protein-coding
Description solute carrier family 4, sodium bicarbonate cotransporter, member 8
Other Description electroneutral Na(+)-driven Cl-HCO3 exchanger|electroneutral sodium bicarbonate exchanger 1|k-NBC3
Swissprots Q8TC60 Q8N3U2 E7EML0 Q2Y0W8 Q9UKX8 A0MMZ1 O95233 B4DHY0 Q004B4 F5H7F5 O94843 F5GZ31
Accessions EAW58191 EAW58192 EAW58193 Q2Y0W8 AB018282 BAA34459 AF069512 AAC82380 AF107099 AAD52981 AI377345 AK056222 AK093005 AK093357 AK124576 AK128321 AK295315 BAG58292 AK299545 BAG61491 AK310017 AL137310 AL831915 CAD38576 AW118662 BC025994 AAH25994 DA521806 DB220099 DQ063579 AAY79176 DQ975204 ABJ09587 DQ996398 ABJ91577 DQ996537 ABJ91576 EU637925 XM_006719700 XP_006719763 XM_011539010 XP_011537312 XM_011539011 XP_011537313 XM_011539012 XP_011537314 XM_011539013 XP_011537315 XM_011539014 XP_011537316 NM_001039960 NP_001035049 NM_001258401 NP_001245330 NM_001258402 NP_001245331 NM_001258403 NP_001245332 NM_001267615 NP_001254544 NR_047672 NM_004858
Function Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. {ECO:0000269|PubMed:10362779, ECO:0000269|PubMed:11133997}.
Subcellular Location Membrane {ECO:0000269|PubMed:17715183}; Multi-pass membrane protein {ECO:0000269|PubMed:17715183}.
Tissue Specificity Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. {ECO:0000269|PubMed:10362779, ECO:0000269|PubMed:11133997, ECO:0000269|PubMed:17715183}.

SLC4A8 CRISPR/Cas9 KO Plasmid (h) - sc-404126 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLC4A8 HDR Plasmid (h) - sc-404126-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLC4A8 Double Nickase Plasmid (h) - sc-404126-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLC4A8 Double Nickase Plasmid (h2) - sc-404126-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLC4A8 CRISPR Activation Plasmid (h) - sc-404126-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLC4A8 CRISPR Activation Plasmid (h2) - sc-404126-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLC4A8 Lentiviral Activation Particles (h) - sc-404126-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLC4A8 Lentiviral Activation Particles (h2) - sc-404126-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SLC4A8 siRNA (h) - sc-95907 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SLC4A8 shRNA Plasmid (h) - sc-95907-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SLC4A8 shRNA (h) Lentiviral Particles - sc-95907-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN19656 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19656 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SLC4A8 siRNA (Human) - CRH6307 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC4A8 RNAi - H00009498-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SLC4A8 - MBS8224578 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human SLC4A8 siRNA - orb266809 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC4A8 shRNA Plasmid (Human) - CHH6307 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC4A8 miRNA 3'UTR clone - MiUTR3H-07300 from Creative biogene

Species Reactivities Human
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