| Gene Symbol |
SLC4A8
|
| Entrez Gene |
9498
|
| Alt Symbol |
NBC3, NDCBE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 4, sodium bicarbonate cotransporter, member 8
|
| Other Description |
electroneutral Na(+)-driven Cl-HCO3 exchanger|electroneutral sodium bicarbonate exchanger 1|k-NBC3
|
| Swissprots |
Q8TC60 Q8N3U2 E7EML0 Q2Y0W8 Q9UKX8 A0MMZ1 O95233 B4DHY0 Q004B4 F5H7F5 O94843 F5GZ31
|
| Accessions |
EAW58191 EAW58192 EAW58193 Q2Y0W8 AB018282 BAA34459 AF069512 AAC82380 AF107099 AAD52981 AI377345 AK056222 AK093005 AK093357 AK124576 AK128321 AK295315 BAG58292 AK299545 BAG61491 AK310017 AL137310 AL831915 CAD38576 AW118662 BC025994 AAH25994 DA521806 DB220099 DQ063579 AAY79176 DQ975204 ABJ09587 DQ996398 ABJ91577 DQ996537 ABJ91576 EU637925 XM_006719700 XP_006719763 XM_011539010 XP_011537312 XM_011539011 XP_011537313 XM_011539012 XP_011537314 XM_011539013 XP_011537315 XM_011539014 XP_011537316 NM_001039960 NP_001035049 NM_001258401 NP_001245330 NM_001258402 NP_001245331 NM_001258403 NP_001245332 NM_001267615 NP_001254544 NR_047672 NM_004858
|
| Function |
Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. {ECO:0000269|PubMed:10362779, ECO:0000269|PubMed:11133997}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:17715183}; Multi-pass membrane protein {ECO:0000269|PubMed:17715183}.
|
| Tissue Specificity |
Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. {ECO:0000269|PubMed:10362779, ECO:0000269|PubMed:11133997, ECO:0000269|PubMed:17715183}.
|