SLC4A8

Gene Symbol	SLC4A8
Entrez Gene	9498
Alt Symbol	NBC3, NDCBE
Species	Human
Gene Type	protein-coding
Description	solute carrier family 4, sodium bicarbonate cotransporter, member 8
Other Description	electroneutral Na(+)-driven Cl-HCO3 exchanger|electroneutral sodium bicarbonate exchanger 1|k-NBC3
Swissprots	Q8TC60 Q8N3U2 E7EML0 Q2Y0W8 Q9UKX8 A0MMZ1 O95233 B4DHY0 Q004B4 F5H7F5 O94843 F5GZ31
Accessions	EAW58191 EAW58192 EAW58193 Q2Y0W8 AB018282 BAA34459 AF069512 AAC82380 AF107099 AAD52981 AI377345 AK056222 AK093005 AK093357 AK124576 AK128321 AK295315 BAG58292 AK299545 BAG61491 AK310017 AL137310 AL831915 CAD38576 AW118662 BC025994 AAH25994 DA521806 DB220099 DQ063579 AAY79176 DQ975204 ABJ09587 DQ996398 ABJ91577 DQ996537 ABJ91576 EU637925 XM_006719700 XP_006719763 XM_011539010 XP_011537312 XM_011539011 XP_011537313 XM_011539012 XP_011537314 XM_011539013 XP_011537315 XM_011539014 XP_011537316 NM_001039960 NP_001035049 NM_001258401 NP_001245330 NM_001258402 NP_001245331 NM_001258403 NP_001245332 NM_001267615 NP_001254544 NR_047672 NM_004858
Function	Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. {ECO:0000269|PubMed:10362779, ECO:0000269|PubMed:11133997}.
Subcellular Location	Membrane {ECO:0000269|PubMed:17715183}; Multi-pass membrane protein {ECO:0000269|PubMed:17715183}.
Tissue Specificity	Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. {ECO:0000269|PubMed:10362779, ECO:0000269|PubMed:11133997, ECO:0000269|PubMed:17715183}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SLC4A8 protein fragment - ab160512 from Abcam Category Protein Source Wheat germ Species Human

SLC4A8 / NBC Antibody Blocking Peptide - LS-E27327 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SLC4A8 Partial Recombinant Protein - H00009498-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SLC4A8-Antibody-N-term-Blocking-Peptide - BP18549a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SLC4A8 blocking peptide - GTX88172-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

SLC4A8 Peptide - AC21-2151-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SLC4A8 - H00009498-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SLC4A8 - H00009498-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SLC4A8 Peptide - 42-553P from ProSci Category Peptide

SLC4A8 fusion protein - ag17416 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SLC4A8 fusion protein - Ag3227 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SLC4A8, Peptide - MBS427240 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

SLC4A8 Peptide, Human - M34GP14603H from Creative Peptides Category Peptide Source Synthetic. Species Human

SLC4A8 Immunizing peptide - orb59777 from Biorbyt Category Peptide

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