Gene Symbol | WDR83 |
---|---|
Entrez Gene | 84292 |
Alt Symbol | MORG1 |
Species | Human |
Gene Type | protein-coding |
Description | WD repeat domain 83 |
Other Description | MAPK organizer 1|WD repeat domain-containing protein 83|mitogen-activated protein kinase organizer 1 |
Swissprots | Q53FT6 B2RAF1 Q9BRX9 |
Accessions | EAW84282 EAW84283 EAW84284 Q9BRX9 AK074525 AK223195 BAD96915 AK314164 BAG36848 BC005870 AAH05870 CB143206 HQ447831 ADQ32315 Z46189 XM_011528358 XP_011526660 NM_001099737 NP_001093207 NM_032332 NP_115708 NR_029375 |
Function | Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}. |
MORG1-Over-expression-Lysate - LY10158a from Abgent, a WuXi AppTec company
|
||||||||
MORG1 293T Cell Transient Overexpression Lysate(Denatured) - H00084292-T01 from Acris Antibodies
|
||||||||
WDR83 overexpression lysate - LY403158 from Acris Antibodies
|
||||||||
WDR83 overexpression lysate - LY420510 from Acris Antibodies
|
||||||||
WDR83 overexpression lysate - LY426085 from Acris Antibodies
|
||||||||
WDR83 293 Cell Lysate - 402744 from ABBIOTEC
|
||||||||
Morg1 Overexpression Lysate (Denatured) - H00084292-T01 from Novus Biologicals
|
||||||||
Morg1 Overexpression Lysate (Native) - NBL1-13185 from Novus Biologicals
|
||||||||
WDR83 Over-expression Lysate Product - GWB-470874 from Genway Biotech
|
||||||||
Morg1 Overexpression Lysate (Native) - NBP2-11426 from Novus Biologicals
|
||||||||
Morg1 Overexpression Lysate (Native) - NBP2-10933 from Novus Biologicals
|
||||||||
Panoply™ Human WDR83 Knockdown Stable Cell Line - CSC-DC017459 from Creative biogene
|