| Gene Symbol | WDR83 |
|---|---|
| Entrez Gene | 84292 |
| Alt Symbol | MORG1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | WD repeat domain 83 |
| Other Description | MAPK organizer 1|WD repeat domain-containing protein 83|mitogen-activated protein kinase organizer 1 |
| Swissprots | Q53FT6 B2RAF1 Q9BRX9 |
| Accessions | EAW84282 EAW84283 EAW84284 Q9BRX9 AK074525 AK223195 BAD96915 AK314164 BAG36848 BC005870 AAH05870 CB143206 HQ447831 ADQ32315 Z46189 XM_011528358 XP_011526660 NM_001099737 NP_001093207 NM_032332 NP_115708 NR_029375 |
| Function | Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}. |