Gene Symbol | WDR83 |
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Entrez Gene | 84292 |
Alt Symbol | MORG1 |
Species | Human |
Gene Type | protein-coding |
Description | WD repeat domain 83 |
Other Description | MAPK organizer 1|WD repeat domain-containing protein 83|mitogen-activated protein kinase organizer 1 |
Swissprots | Q53FT6 B2RAF1 Q9BRX9 |
Accessions | EAW84282 EAW84283 EAW84284 Q9BRX9 AK074525 AK223195 BAD96915 AK314164 BAG36848 BC005870 AAH05870 CB143206 HQ447831 ADQ32315 Z46189 XM_011528358 XP_011526660 NM_001099737 NP_001093207 NM_032332 NP_115708 NR_029375 |
Function | Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}. |
Human Morg1 full length protein - ab164558 from Abcam
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Human Morg1 protein fragment - ab164559 from Abcam
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WDR83 Antibody Blocking Peptide - LS-E22101 from LifeSpan Bioscience
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WDR83 Antibody Blocking Peptide - LS-E10203 from LifeSpan Bioscience
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Recombinant Human Morg1 Protein - H00084292-P01 from Novus Biologicals
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Recombinant Human Morg1 Protein - H00084292-Q01 from Novus Biologicals
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MORG1-Antibody-Center-Blocking-Peptide - BP9575c from Abgent, a WuXi AppTec company
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WDR83 Blocking Peptide - 33R-2419 from Fitzgerald
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MORG1 - H00084292-P01-10 from Acris Antibodies
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MORG1 - H00084292-P01-25 from Acris Antibodies
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MORG1 - H00084292-Q01-10 from Acris Antibodies
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MORG1 - H00084292-Q01-25 from Acris Antibodies
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MORG1 fusion protein - ag14801 from Proteintech Group
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MORG1 fusion protein - ag15141 from Proteintech Group
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Recombinant Human WD repeat domain-containing protein 83(WDR83) - CSB-YP863110HU CSB-EP863110HU CSB-BP863110HU CSB-MP863110HU from Cusabio
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MORG1 (transcript variant 2) - TP301323 from Acris Antibodies
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MORG1 (transcript variant 1) - TP315520 from Acris Antibodies
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WD repeat domain-containing protein 83 (WDR83) , Recombinant Protein - MBS1333307 from MyBioSource
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Morg1 Recombinant Protein Antigen - NBP1-92133PEP from Novus Biologicals
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Morg1 Protein - NBP1-92132PEP from Novus Biologicals
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WDR83 Peptide, Human - M34GP17459H from Creative Peptides
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Recombinant Human WDR83 Protein, GST-tagged - WDR83-5286H from Creative Biomart
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