| Gene Symbol | GUCA1A |
|---|---|
| Entrez Gene | 2978 |
| Alt Symbol | C6orf131, COD3, CORD14, GCAP, GCAP1, GUCA, GUCA1, dJ139D8.6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | guanylate cyclase activator 1A (retina) |
| Other Description | GCAP 1|cone dystrophy 3|guanylate cyclase-activating protein, photoreceptor 1|guanylin 1, retina|guanylyl cyclase-activating protein 1 |
| Swissprots | Q9NU14 B3KWT4 Q7Z6T1 P43080 |
| Accessions | AAA60542 AFK80059 AFK80060 EAX04084 P43080 AK125780 BAG54246 AK313865 BAG36593 BC031663 AAH31663 DB049592 DQ891302 ABM82228 DQ894487 ABM85413 L36859 AAA60541 XM_006715073 XP_006715136 XM_011514536 XP_011512838 XM_011514537 XP_011512839 XM_011514538 XP_011512840 XM_011514539 XP_011512841 NM_000409 NP_000400 |
| Function | Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. |
| Subcellular Location | Membrane; Lipid-anchor. |
| Tissue Specificity | Retina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments. |
| Top Pathways | Olfactory transduction, Phototransduction |