| Gene Symbol |
GUCA1A
|
| Entrez Gene |
2978
|
| Alt Symbol |
C6orf131, COD3, CORD14, GCAP, GCAP1, GUCA, GUCA1, dJ139D8.6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
guanylate cyclase activator 1A (retina)
|
| Other Description |
GCAP 1|cone dystrophy 3|guanylate cyclase-activating protein, photoreceptor 1|guanylin 1, retina|guanylyl cyclase-activating protein 1
|
| Swissprots |
Q9NU14 B3KWT4 Q7Z6T1 P43080
|
| Accessions |
AAA60542 AFK80059 AFK80060 EAX04084 P43080 AK125780 BAG54246 AK313865 BAG36593 BC031663 AAH31663 DB049592 DQ891302 ABM82228 DQ894487 ABM85413 L36859 AAA60541 XM_006715073 XP_006715136 XM_011514536 XP_011512838 XM_011514537 XP_011512839 XM_011514538 XP_011512840 XM_011514539 XP_011512841 NM_000409 NP_000400
|
| Function |
Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.
|
| Subcellular Location |
Membrane; Lipid-anchor.
|
| Tissue Specificity |
Retina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments.
|
| Top Pathways |
Olfactory transduction, Phototransduction
|
![Western Blot: GCAP1 Overexpression Lysate (Adult Normal) [NBL1-11406] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GCAP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/759_GCAP1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11406-img0002.jpg)