Gene Symbol |
LIPE
|
Entrez Gene |
3991
|
Alt Symbol |
AOMS4, FPLD6, HSL, LHS
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
lipase, hormone-sensitive
|
Other Description |
hormone-sensitive lipase|hormone-sensitive lipase testicular isoform
|
Swissprots |
Q6NSL7 Q3LRT2 Q05469
|
Accessions |
AAA69810 ABA03168 EAW57135 Q05469 AK292482 BAF85171 AK309893 BC029301 BC029961 BC070041 AAH70041 U40002 AAC50666 XM_005258937 XP_005258994 XM_005258938 XP_005258995 XM_005258939 XP_005258996 XM_005258940 XP_005258997 XM_005258941 XP_005258998 XM_006723218 XP_006723281 NM_005357 NP_005348
|
Function |
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
|
Subcellular Location |
Cell membrane. Membrane, caveola. Cytoplasm, cytosol. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.
|
Top Pathways |
Insulin signaling pathway, AMPK signaling pathway, cAMP signaling pathway
|