| Gene Symbol |
MPL
|
| Entrez Gene |
4352
|
| Alt Symbol |
C-MPL, CD110, MPLV, THCYT2, TPOR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MPL proto-oncogene, thrombopoietin receptor
|
| Other Description |
TPO-R|myeloproliferative leukemia protein|myeloproliferative leukemia virus oncogene|proto-oncogene c-Mpl|thrombopoietin receptor
|
| Swissprots |
Q5JUZ0 P40238
|
| Accessions |
AAB08424 AAB08425 EAX07103 EAX07104 EAX07105 P40238 BC140298 AAI40299 BC153092 AAI53093 DQ234353 ABB29982 KF964490 AHL44293 M90102 AAA69971 M90103 AAA69972 XM_011541478 XP_011539780 NM_005373 NP_005364
|
| Function |
Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
|
