MPL

Gene Symbol MPL
Entrez Gene 4352
Alt Symbol C-MPL, CD110, MPLV, THCYT2, TPOR
Species Human
Gene Type protein-coding
Description MPL proto-oncogene, thrombopoietin receptor
Other Description TPO-R|myeloproliferative leukemia protein|myeloproliferative leukemia virus oncogene|proto-oncogene c-Mpl|thrombopoietin receptor
Swissprots Q5JUZ0 P40238
Accessions AAB08424 AAB08425 EAX07103 EAX07104 EAX07105 P40238 BC140298 AAI40299 BC153092 AAI53093 DQ234353 ABB29982 KF964490 AHL44293 M90102 AAA69971 M90103 AAA69972 XM_011541478 XP_011539780 NM_005373 NP_005364
Function Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Phospho-TPOR (Tyr626) (D3H7B) Rabbit mAb - 12712 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3H7B
Western blot analysis of extracts from serum-starved BaF3 cells or serum-starved BaF3 cells stably expressing mouse thrombopoietin receptor (mTPOR), untreated (-) or treated with recombinant mouse thrombopoietin (mTPO; 100 ng/mL, 10 min; +), using Phospho-TPOR (Tyr626) (D3H7B) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

c-Mpl (N-20) - sc-13187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
c-Mpl (N-20): sc-13187. Western blot analysis of c-Mpl expression in Daudi (A) and U266 (B) whole cell lysates.

c-Mpl (E-7) - sc-377417 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
c-Mpl (E-7): sc-377417. Western blot analysis of c-Mpl expression in Ramos (A) and U266 (B) whole cell lysates.

c-Mpl (H-300) - sc-15403 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-TPOR antibody - ab172061 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TPOR antibody (ab172061) at 1 µg/mlLane 1 : TPOR transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-TPOR antibody - ab70194 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-TPOR antibody [EPR4194] - ab109003 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4194
Overlay histogram showing MOLT4 cells stained with ab109003 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab109003, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-rabbit IgG (H+L) (ab96899) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-CD110 / MPL Antibody (aa311-460) - LS-C295474 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CD110 / MPL.

Anti-CD110 / MPL Antibody (C-Terminus, clone EPR4194) - LS-C138077 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4194
Western blot analysis on (A) HepG2, (B) A431, and (C) human marrow lysates using anti-TPOR antibody.

Anti-CD110 / MPL Antibody (aa66-260) - LS-C295475 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CD110 / MPL.

Anti-CD110 / MPL Antibody (aa615-628) - LS-C26341 from LifeSpan Bioscience

Prices $475.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
WB: DAMI cell lysate probed with LS-C26341 (0.5 ug/ml).

Anti-CD110 / MPL Antibody (clone 1H2) - LS-C169168 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1H2
Western blot using MPL monoclonal antibody against human MPL (AA: 307-362) recombinant protein. (Expected MW is 32.2 kDa)

Anti-CD110 / MPL Antibody (PE) - LS-C144232 from LifeSpan Bioscience

Prices $530.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-CD110 / MPL Antibody (aa1-635) - LS-C132438 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD110 / MPL Antibody (C-Terminus) - LS-C193945 from LifeSpan Bioscience

Prices $905.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD110 / MPL Antibody (aa311-460, Biotin) - LS-C299499 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD110 / MPL Antibody (aa66-260, FITC) - LS-C303599 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD110 / MPL Antibody (aa311-460, FITC) - LS-C303587 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CD110 / MPL Antibody (aa66-260, Biotin) - LS-C299513 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Thrombopoietin R/Tpo R Antibody - AF1016 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Recombinant Human Thrombopoietin/Tpo (Catalog # 288-TP) stimulates proliferation in the MO7e human megakaryocytic leukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human Thrombopoietin/Tpo (10 ng/mL) is neutralized (green line) by increasing concen­trations of Goat Anti-Human Thrombopoietin R/Tpo R Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1016). The ND50 is typically 0.5‑2.5 µg/mL.

Thrombopoietin R/Tpo R Antibody - AF1317 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

Thrombopoietin R/Tpo R Antibody (1H2) - NBP2-37529 from Novus Biologicals

Prices $369.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H2
Western Blot: Thrombopoietin R/Tpo R Antibody (1H2) [NBP2-37529] - Western blot analysis using MPL mAb against human MPL (AA: 307-362) recombinant protein. (Expected MW is 32.2 kDa)

Thrombopoietin R/Tpo R Antibody (EPR4194) - NBP1-95467 from Novus Biologicals

Host Rabbit
Clonality Monoclonal
Clone EPR4194
Western Blot: TPOR Antibody (EPR4194) [NBP1-95467] (A) HepG2, (B) A431, and © human marrow lysates.

Thrombopoietin R/Tpo R Antibody - H00004352-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Thrombopoietin R/Tpo R Antibody [H00004352-B01P] - Analysis of MPL expression in transfected 293T cell line by MPL polyclonal antibody. Lane1:MPL transfected lysate(69.85 KDa). Lane2:Non-transfected lysate.

Thrombopoietin R/Tpo R Antibody - H00004352-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Thrombopoietin R/Tpo R Antibody [H00004352-D01P] - Analysis of MPL expression in transfected 293T cell line by MPL polyclonal antibody.Lane 1: MPL transfected lysate(71.20 KDa).Lane 2: Non-transfected lysate.
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