UNC13A

Gene Symbol UNC13A
Entrez Gene 23025
Alt Symbol Munc13-1
Species Human
Gene Type protein-coding
Description unc-13 homolog A (C. elegans)
Other Description protein unc-13 homolog A
Swissprots E5RHY9 Q9UPW8
Accessions Q9UPW8 AB028955 BAA82984 AK055065 BC011004 BC172223 AAI72223 DA236619 R60139 XM_011527809 XP_011526111 XM_011527810 XP_011526112 XM_011527811 XP_011526113 XM_011527812 XP_011526114 XM_011527813 XP_011526115 NM_001080421 NP_001073890
Function Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol ester binding (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in pancreatic islet cells. {ECO:0000269|PubMed:12871971}.
Top Pathways Synaptic vesicle cycle

Anti-Munc 13 antibody - ab101740 from Abcam

Host Rabbit
Clonality Polyclonal
ICC/IF image of ab101740 stained PANC-1 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab101740 at 5 µg/mL overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti-rabbit IgG (H+L) (ab96899) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Munc 13 antibody [Munc13-71] - ab50566 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone Munc13-71

Anti-UNC13A Antibody (aa1613-1786) - LS-C130624 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

UNC13A/Munc13-1 Antibody - AF6214 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal

UNC13A/Munc13-1 Antibody - NBP1-87895 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UNC13A/Munc13-1 Antibody - NBP1-70357 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC13A antibody produced in rabbit - HPA041418 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-UNC13A: <B>Cat. No. HPA041418</B>: Immunohistochemical staining of human nasopharynx shows distinct membranous positivity in respiratory epithelial cells.

Human/Mouse UNC13A Antibody - AF6214 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Detection of Human and Mouse UNC13A by Western Blot. Western blot shows lysates of human brain (hippocampus) tissue and mouse brain tissue. PVDF Membrane was probed with 2 µg/mL of Sheep Anti-Human/Mouse UNC13A Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6214) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). A specific band was detected for UNC13A at approximately 190-210 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2 .

Human/Mouse UNC13A Affinity Purified Polyclonal Ab, Sheep IgG - AF6214-SP from R&D Systems

Host Sheep
Clonality Polyclonal
Detection of Human and Mouse UNC13A by Western Blot. Western blot shows lysates of human brain (hippocampus) tissue and mouse brain tissue. PVDF Membrane was probed with 2 µg/mL of Sheep Anti-Human/Mouse UNC13A Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6214) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for UNC13A at approximately 190-210 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.

UNC13A antibody - 70R-21167 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

UNC13A/Munc13-1 antibody - 55053-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Human brain tissue were subjected to SDS PAGE followed by western blot with 55053-1-AP(UNC13A antibody) at dilution of 1:300

UNC13A/Munc13-1 antibody - 55053-1-AP from Proteintech Group

Prices $279.00
Sizes con: 49 μg/150μl
Host Rabbit
Clonality Polyclonal
human brain tissue were subjected to SDS PAGE followed by western blot with 55053-1-AP(UNC13A antibody) at dilution of 1:300

Rabbit Anti-Human UNC13A Polyclonal antibody - DPABH-04641 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

UNC13B - MBS273708 from MyBioSource

Prices $360.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: Hela 5% SDS PAGE diluted at 1:5000

UNC13B - MBS272615 from MyBioSource

Prices $360.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: 293T 5% SDS PAGE Diluted at 1:500

anti-UNC13A/Munc13-1 antibody - A009255 from Biobool

Host Rabbit
Clonality Polyclonal
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