| Gene Symbol |
UNC13A
|
| Entrez Gene |
23025
|
| Alt Symbol |
Munc13-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
unc-13 homolog A (C. elegans)
|
| Other Description |
protein unc-13 homolog A
|
| Swissprots |
E5RHY9 Q9UPW8
|
| Accessions |
Q9UPW8 AB028955 BAA82984 AK055065 BC011004 BC172223 AAI72223 DA236619 R60139 XM_011527809 XP_011526111 XM_011527810 XP_011526112 XM_011527811 XP_011526113 XM_011527812 XP_011526114 XM_011527813 XP_011526115 NM_001080421 NP_001073890
|
| Function |
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol ester binding (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in pancreatic islet cells. {ECO:0000269|PubMed:12871971}.
|
| Top Pathways |
Synaptic vesicle cycle
|