UNC13A

Gene Symbol UNC13A
Entrez Gene 23025
Alt Symbol Munc13-1
Species Human
Gene Type protein-coding
Description unc-13 homolog A (C. elegans)
Other Description protein unc-13 homolog A
Swissprots E5RHY9 Q9UPW8
Accessions Q9UPW8 AB028955 BAA82984 AK055065 BC011004 BC172223 AAI72223 DA236619 R60139 XM_011527809 XP_011526111 XM_011527810 XP_011526112 XM_011527811 XP_011526113 XM_011527812 XP_011526114 XM_011527813 XP_011526115 NM_001080421 NP_001073890
Function Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol ester binding (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in pancreatic islet cells. {ECO:0000269|PubMed:12871971}.
Top Pathways Synaptic vesicle cycle

unc-13 homolog A (C. elegans) , ELISA Kit - MBS9338373 from MyBioSource

Category ELISA Kit
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Human UNC13A ELISA Kit - E102166 from Biobool

Category ELISA Kit

Protein Unc-13 Homolog A (UNC13A), ELISA Kit - MBS9364015 from MyBioSource

Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Category ELISA Kit
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Category ELISA Kit
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Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Category ELISA Kit
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Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Category ELISA Kit
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Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Category ELISA Kit
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Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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