UNC13A

Gene Symbol UNC13A
Entrez Gene 23025
Alt Symbol Munc13-1
Species Human
Gene Type protein-coding
Description unc-13 homolog A (C. elegans)
Other Description protein unc-13 homolog A
Swissprots E5RHY9 Q9UPW8
Accessions Q9UPW8 AB028955 BAA82984 AK055065 BC011004 BC172223 AAI72223 DA236619 R60139 XM_011527809 XP_011526111 XM_011527810 XP_011526112 XM_011527811 XP_011526113 XM_011527812 XP_011526114 XM_011527813 XP_011526115 NM_001080421 NP_001073890
Function Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol ester binding (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in pancreatic islet cells. {ECO:0000269|PubMed:12871971}.
Top Pathways Synaptic vesicle cycle

Munc13-1 CRISPR/Cas9 KO Plasmid (h) - sc-409829 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-1 HDR Plasmid (h) - sc-409829-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-1 Double Nickase Plasmid (h) - sc-409829-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-1 Double Nickase Plasmid (h2) - sc-409829-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-1 CRISPR Activation Plasmid (h) - sc-409829-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-1 CRISPR Activation Plasmid (h2) - sc-409829-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-1 Lentiviral Activation Particles (h) - sc-409829-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-1 Lentiviral Activation Particles (h2) - sc-409829-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Munc13-1 siRNA (h) - sc-42020 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Munc13-1 shRNA Plasmid (h) - sc-42020-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Munc13-1 shRNA (h) Lentiviral Particles - sc-42020-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU160641 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22493 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22493 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

UNC13A siRNA (Human) - CRH7939 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UNC13A - MBS8237750 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UNC13A (NM_001080421.2) - SHH440476 from Creative biogene

Category siRNA
Species Reactivities Human

Human UNC13A siRNA - orb268441 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UNC13A shRNA Plasmid (Human) - CHH7939 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
Search more