Gene Symbol | Gsk3a |
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Entrez Gene | 606496 |
Alt Symbol | 2700086H06Rik |
Species | Mouse |
Gene Type | protein-coding |
Description | glycogen synthase kinase 3 alpha |
Other Description | GSK-3 alpha|glycogen synthase kinase-3 alpha|serine/threonine-protein kinase GSK3A |
Swissprots | Q2NL51 |
Accessions | EDL24285 Q2NL51 AK203093 AK203119 AK214774 AV131869 AW046583 BC111032 AAI11033 BC152757 AAI52758 BC156581 AAI56582 BE847593 BI987440 BQ885209 CK624130 XM_006540258 XP_006540321 XM_006540259 XP_006540322 NM_001031667 NP_001026837 |
Function | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establish |
Top Pathways | Chemokine signaling pathway, Dopaminergic synapse, Non-alcoholic fatty liver disease (NAFLD) |
Mouse-Gsk3a-Antibody-C-term - AP14846b from Abgent, a WuXi AppTec company
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Mouse Gsk3a Antibody - C-terminal region (OAAB11177) - OAAB11177 from Aviva Systems Biology
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GSK3 alpha antibody (Ser21) - 70R-37089 from Fitzgerald
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GSK3 alpha antibody - 70R-37447 from Fitzgerald
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Anti -Glycogen Synthase Kinase 3 Alpha (GSK3a) - 151805 from USBiological Life Science
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Anti -Glycogen Synthase Kinase 3 Alpha (GSK3a) (AP) - 151805-AP from USBiological Life Science
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Anti -Glycogen Synthase Kinase 3 Alpha (GSK3a) (APC) - 151805-APC from USBiological Life Science
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Anti -Glycogen Synthase Kinase 3 Alpha (GSK3a) (Biotin) - 151805-Biotin from USBiological Life Science
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Anti -Glycogen Synthase Kinase 3 Alpha (GSK3a) (FITC) - 151805-FITC from USBiological Life Science
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Anti -Glycogen Synthase Kinase 3 Alpha (GSK3a) (HRP) - 151805-HRP from USBiological Life Science
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Anti -Glycogen Synthase Kinase 3 Alpha (GSK3a) (PE) - 151805-PE from USBiological Life Science
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Anti -Gsk3a, CT (Gsk3a, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinaseGSK3A) - 036331 from USBiological Life Science
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Anti -Gsk3a, CT (Gsk3a, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinaseGSK3A) (AP) - 036331-AP from USBiological Life Science
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Anti -Gsk3a, CT (Gsk3a, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinaseGSK3A) (APC) - 036331-APC from USBiological Life Science
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Anti -Gsk3a, CT (Gsk3a, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinaseGSK3A) (Azide free) (HRP) - 036331-HRP from USBiological Life Science
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Anti -Gsk3a, CT (Gsk3a, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinaseGSK3A) (Biotin) - 036331-Biotin from USBiological Life Science
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Anti -Gsk3a, CT (Gsk3a, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinaseGSK3A) (FITC) - 036331-FITC from USBiological Life Science
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Anti -Gsk3a, CT (Gsk3a, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinaseGSK3A) (PE) - 036331-PE from USBiological Life Science
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GSK3 alpha antibody (Ser21) - 70R-34163 from Fitzgerald
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GSK3 alpha antibody - 70R-34164 from Fitzgerald
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GSK3a Antibody - abx103422 from Abbexa
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Mouse Gsk3a Antibody - abx028353 from Abbexa
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Rabbit Anti-Mouse Mouse Gsk3a (C-term) - 102-12682 from RayBiotech
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Gsk3a antibody (C-term) - STJ44386 from St John's Laboratory Ltd
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Mouse Anti-GSK-3, Antibody - GWB-BEE5DC from Genway Biotech
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