| Gene Symbol |
Gsk3a
|
| Entrez Gene |
606496
|
| Alt Symbol |
2700086H06Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
glycogen synthase kinase 3 alpha
|
| Other Description |
GSK-3 alpha|glycogen synthase kinase-3 alpha|serine/threonine-protein kinase GSK3A
|
| Swissprots |
Q2NL51
|
| Accessions |
EDL24285 Q2NL51 AK203093 AK203119 AK214774 AV131869 AW046583 BC111032 AAI11033 BC152757 AAI52758 BC156581 AAI56582 BE847593 BI987440 BQ885209 CK624130 XM_006540258 XP_006540321 XM_006540259 XP_006540322 NM_001031667 NP_001026837
|
| Function |
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establish
|
| Top Pathways |
Chemokine signaling pathway, Dopaminergic synapse, Non-alcoholic fatty liver disease (NAFLD)
|