Gene Symbol | Gsk3a |
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Entrez Gene | 606496 |
Alt Symbol | 2700086H06Rik |
Species | Mouse |
Gene Type | protein-coding |
Description | glycogen synthase kinase 3 alpha |
Other Description | GSK-3 alpha|glycogen synthase kinase-3 alpha|serine/threonine-protein kinase GSK3A |
Swissprots | Q2NL51 |
Accessions | EDL24285 Q2NL51 AK203093 AK203119 AK214774 AV131869 AW046583 BC111032 AAI11033 BC152757 AAI52758 BC156581 AAI56582 BE847593 BI987440 BQ885209 CK624130 XM_006540258 XP_006540321 XM_006540259 XP_006540322 NM_001031667 NP_001026837 |
Function | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establish |
Top Pathways | Chemokine signaling pathway, Dopaminergic synapse, Non-alcoholic fatty liver disease (NAFLD) |
Glycogen Synthase Kinase 3 Alpha, Mouse, ELISA Kit - E03G0264 from ARP American Research Products
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Glycogen synthase kinase-3 alpha (GSK3A), Mouse, ELISA Kit - CSB-E08876m from ARP American Research Products
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Glycogen synthase kinase-3 alpha, Gsk3a, Mouse, ELISA Kit - E0767m from ARP American Research Products
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Mouse GSK3a ELISA Kit - MG0271 from NeoScientific
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Mouse GSK3α(Glycogen Synthase Kinase 3 Alpha) ELISA Kit - E-EL-M0586 from Elabscience
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Mouse GSK3a (Glycogen Synthase Kinase 3 Alpha) CLIA Kit - E-CL-M0353 from Elabscience
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glycogen synthase kinase 3 alpha, ELISA Kit - MBS702889 from MyBioSource
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Mouse Glycogen synthase kinase-3 alpha(GSK3A) ELISA kit - CSB-E08876m from Cusabio
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Mouse GSK3Alpha(Glycogen Synthase Kinase 3 Alpha) ELISA Kit - E-EL-M0586 from Iwai North America Inc.
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Mouse GSK3a (Glycogen Synthase Kinase 3 Alpha) CLIA Kit - E-CL-M0353 from Iwai North America Inc.
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Mouse Glycogen synthase kinase-3 alpha ELISA Kit - abx254668 from Abbexa
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Mouse Glycogen synthase kinase-3 alpha (GSK3A) ELISA Kit - EKC36977 from Biomatik
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Mouse Glycogen synthase kinase-3 alpha ELISA Kit - EKE51682 from Biomatik
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Gsk3α - EKM618 from Nordic BioSite
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Mouse GSK3a ELISA Kit - E055024 from Biobool
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GSK3A ELISA Kit (Mouse) (OKEH04107) - OKEH04107 from Aviva Systems Biology
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Mouse GSK3a ELISA Kit - EMG0271 from ABclonal
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Glycogen synthase kinase-3 alpha, ELISA Kit - MBS2882047 from MyBioSource
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Mouse GSK3A ELISA Kit - orb409393 from Biorbyt
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