Gsk3a

Gene Symbol	Gsk3a
Entrez Gene	606496
Alt Symbol	2700086H06Rik
Species	Mouse
Gene Type	protein-coding
Description	glycogen synthase kinase 3 alpha
Other Description	GSK-3 alpha|glycogen synthase kinase-3 alpha|serine/threonine-protein kinase GSK3A
Swissprots	Q2NL51
Accessions	EDL24285 Q2NL51 AK203093 AK203119 AK214774 AV131869 AW046583 BC111032 AAI11033 BC152757 AAI52758 BC156581 AAI56582 BE847593 BI987440 BQ885209 CK624130 XM_006540258 XP_006540321 XM_006540259 XP_006540322 NM_001031667 NP_001026837
Function	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establish
Top Pathways	Chemokine signaling pathway, Dopaminergic synapse, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

SignalSilence ® GSK-3α siRNA I (Mouse Specific) - 6333 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® GSK-3α siRNA II (Mouse Specific) - 6335 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

GSK-3α CRISPR/Cas9 KO Plasmid (m) - sc-436875 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

GSK-3α HDR Plasmid (m) - sc-436875-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

GSK-3α Double Nickase Plasmid (m) - sc-436875-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

GSK-3α Double Nickase Plasmid (m2) - sc-436875-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

GSK-3α CRISPR Activation Plasmid (m) - sc-436875-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

GSK-3α CRISPR Activation Plasmid (m2) - sc-436875-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

GSK-3α Lentiviral Activation Particles (m) - sc-436875-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

GSK-3α Lentiviral Activation Particles (m2) - sc-436875-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

GSK-3α siRNA (m) - sc-35526 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

GSK-3α shRNA Plasmid (m) - sc-35526-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

GSK-3α shRNA (m) Lentiviral Particles - sc-35526-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU170441 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN32896 from Sigma-Aldrich Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND32896 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

GSK3A siRNA (Mouse) - CRN5176 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

GSK3A - MBS8202658 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse GSK3A (NM_001031667.1) - SHH308462 from Creative biogene Category siRNA Species Reactivities Mouse

shRNA set against Mouse Gsk3a(NM_001031667.1) - SHH106751 from Creative biogene Category siRNA Species Reactivities Mouse

GSK-3α siRNA (m2) - sc-270018 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

GSK-3α shRNA Plasmid (m2) - sc-270018-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

GSK-3α shRNA (m2) Lentiviral Particles - sc-270018-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

Mouse GSK3A siRNA - orb294651 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

GSK3A shRNA Plasmid (Mouse) - CHN5176 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

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