| Gene Symbol |
FGD2
|
| Entrez Gene |
221472
|
| Alt Symbol |
ZFYVE4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FYVE, RhoGEF and PH domain containing 2
|
| Other Description |
FGD1 family, member 2|FLJ00276 protein|FYVE, RhoGEF and PH domain-containing protein 2|zinc finger FYVE domain-containing protein 4
|
| Swissprots |
Q9H7M2 Q7Z6J4 Q8N868 Q5T8I1 Q8IZ32 Q6ZNL5 Q6P6A8
|
| Accessions |
EAX03932 EAX03933 Q7Z6J4 AK024456 BAB15746 AK092732 AK097230 BAC04982 AK097981 AK098248 AK131079 BAC85129 AK290419 BAF83108 AK300964 BAG62589 AK301156 BAG62746 BC023645 AAH23645 BC053655 AAH53655 BC062363 BX648164 DQ893612 ABM84538 DQ894928 ABM85854 XM_005248911 XP_005248968 XM_005248912 XP_005248969 XM_005248913 XP_005248970 XM_005248914 XP_005248971 XM_006715016 XP_006715079 XM_011514371 XP_011512673 XM_011514372 XP_011512674 XM_011514373 XP_011512675 XM_011514374 XP_011512676 XR_926106 NM_173558 NP_775829
|
| Function |
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Early endosome {ECO:0000250}. Early endosome membrane {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. {ECO:0000250}.
|