| Gene Symbol | PRKCZ |
|---|---|
| Entrez Gene | 5590 |
| Alt Symbol | PKC-ZETA, PKC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase C, zeta |
| Other Description | nPKC-zeta|protein kinase C zeta type |
| Swissprots | A8K4N0 A8MU64 Q05513 B7Z2J7 Q15207 Q5SYT5 Q969S4 E9PCW2 |
| Accessions | EAW56130 EAW56131 Q05513 AB007974 AK097627 BAG53497 AK131526 AK290995 BAF83684 AK294649 BAH11833 AK294782 BAH11883 AK302160 BAH13641 AK310372 AL542576 AU134793 BC008058 AAH08058 BC014270 AAH14270 BT007082 AAP35745 CB152283 DC312466 DQ892929 ABM83855 DQ893922 ABM84848 DQ896178 ABM87177 L14283 AAA36488 Z15108 CAA78813 XM_011541773 XP_011540075 XM_011541774 XP_011540076 XM_011541775 XP_011540077 XM_011541776 XP_011540078 XM_011541777 XP_011540079 XM_011541778 XP_011540080 XM_011541779 XP_011540081 XM_011541780 XP_011540082 XR_946707 XR_946708 NM_001033581 NP_001028753 NM_001033582 NP_001028754 NM_001242874 NP_001229803 NM_002744 NP_002735 |
| Function | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN p |
| Subcellular Location | Cytoplasm. Endosome. Cell junction. Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}. |
| Tissue Specificity | Expressed in brain, and to a lesser extent in lung, kidney and testis. |
| Top Pathways | Chemokine signaling pathway, Sphingolipid signaling pathway, Rap1 signaling pathway, Hippo signaling pathway, PI3K-Akt signaling pathway |