PRKCZ

Gene Symbol	PRKCZ
Entrez Gene	5590
Alt Symbol	PKC-ZETA, PKC2
Species	Human
Gene Type	protein-coding
Description	protein kinase C, zeta
Other Description	nPKC-zeta|protein kinase C zeta type
Swissprots	A8K4N0 A8MU64 Q05513 B7Z2J7 Q15207 Q5SYT5 Q969S4 E9PCW2
Accessions	EAW56130 EAW56131 Q05513 AB007974 AK097627 BAG53497 AK131526 AK290995 BAF83684 AK294649 BAH11833 AK294782 BAH11883 AK302160 BAH13641 AK310372 AL542576 AU134793 BC008058 AAH08058 BC014270 AAH14270 BT007082 AAP35745 CB152283 DC312466 DQ892929 ABM83855 DQ893922 ABM84848 DQ896178 ABM87177 L14283 AAA36488 Z15108 CAA78813 XM_011541773 XP_011540075 XM_011541774 XP_011540076 XM_011541775 XP_011540077 XM_011541776 XP_011540078 XM_011541777 XP_011540079 XM_011541778 XP_011540080 XM_011541779 XP_011540081 XM_011541780 XP_011540082 XR_946707 XR_946708 NM_001033581 NP_001028753 NM_001033582 NP_001028754 NM_001242874 NP_001229803 NM_002744 NP_002735
Function	Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN p
Subcellular Location	Cytoplasm. Endosome. Cell junction. Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.
Tissue Specificity	Expressed in brain, and to a lesser extent in lung, kidney and testis.
Top Pathways	Chemokine signaling pathway, Sphingolipid signaling pathway, Rap1 signaling pathway, Hippo signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® PKCζ siRNA II - 8939 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® PKCζ siRNA I - 8672 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

PKC ζ siRNA (h) - sc-29451 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC ζ shRNA Plasmid (h) - sc-29451-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC ζ shRNA (h) Lentiviral Particles - sc-29451-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC ζ siRNA (h2) - sc-44270 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC ζ shRNA Plasmid (h2) - sc-44270-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC ζ shRNA (h2) Lentiviral Particles - sc-44270-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC zeta RNAi - H00005590-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PKC zeta RNAi - H00005590-R07 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

PKC zeta RNAi - H00005590-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU026811 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1844 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1842 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1843 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1057 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1057 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03402 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr03402

PRKCZ siRNA (Human) - CRH3760 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PKC zeta RNAi - H00005590-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human PRKCZ (NM_002744.4) - SHH382900 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PRKCZ(NM_001033581.1) - SHR140620 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PRKCZ(NM_002744.4) - SHR140694 from Creative biogene Category siRNA Species Reactivities Human

PRKCZ shRNA Plasmid (Human) - CHH3760 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PRKCZ miRNA 3'UTR clone - MiUTR1H-08281 from Creative biogene Species Reactivities Human

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