PRKCZ

Gene Symbol	PRKCZ
Entrez Gene	5590
Alt Symbol	PKC-ZETA, PKC2
Species	Human
Gene Type	protein-coding
Description	protein kinase C, zeta
Other Description	nPKC-zeta|protein kinase C zeta type
Swissprots	A8K4N0 A8MU64 Q05513 B7Z2J7 Q15207 Q5SYT5 Q969S4 E9PCW2
Accessions	EAW56130 EAW56131 Q05513 AB007974 AK097627 BAG53497 AK131526 AK290995 BAF83684 AK294649 BAH11833 AK294782 BAH11883 AK302160 BAH13641 AK310372 AL542576 AU134793 BC008058 AAH08058 BC014270 AAH14270 BT007082 AAP35745 CB152283 DC312466 DQ892929 ABM83855 DQ893922 ABM84848 DQ896178 ABM87177 L14283 AAA36488 Z15108 CAA78813 XM_011541773 XP_011540075 XM_011541774 XP_011540076 XM_011541775 XP_011540077 XM_011541776 XP_011540078 XM_011541777 XP_011540079 XM_011541778 XP_011540080 XM_011541779 XP_011540081 XM_011541780 XP_011540082 XR_946707 XR_946708 NM_001033581 NP_001028753 NM_001033582 NP_001028754 NM_001242874 NP_001229803 NM_002744 NP_002735
Function	Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN p
Subcellular Location	Cytoplasm. Endosome. Cell junction. Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.
Tissue Specificity	Expressed in brain, and to a lesser extent in lung, kidney and testis.
Top Pathways	Chemokine signaling pathway, Sphingolipid signaling pathway, Rap1 signaling pathway, Hippo signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PKC zeta full length protein - ab60848 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PKC zeta full length protein - ab159212 from Abcam Category Protein Source Wheat germ Species Human

Human PKC zeta protein fragment - ab159213 from Abcam Category Protein Source Wheat germ Species Human

PRKCZ / PKC-Zeta Antibody Blocking Peptide - LS-E3119 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCZ / PKC-Zeta Antibody Blocking Peptide - LS-E29401 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PRKCZ / PKC-Zeta Antibody Blocking Peptide - LS-E29402 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PRKCZ / PKC-Zeta Antibody Blocking Peptide - LS-E15778 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCZ / PKC-Zeta Antibody Blocking Peptide - LS-E8618 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PKC zeta Protein - H00005590-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PKC zeta Protein - H00005590-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PKC zeta Recombinant Protein - P4202 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

PKC zeta Recombinant Protein - P4764 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant PKC zeta Protein - NBP1-99885 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

PKC-zeta-Antibody-N-term-Blocking-Peptide - BP7028a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRKCZ peptide - orb219160 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Rabbit, Zebrafish, Monkey

PRKCZ Blocking Peptide - 33R-5876 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Protein Kinase C Zeta Protein - abx068754 from Abbexa Category Protein Source E.coli Species Human

PRKCZ - H00005590-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PRKCZ - H00005590-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PRKCZ - H00005590-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKCZ - H00005590-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKCZ - P4202 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

PRKCZ - P4764 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

PRKCZ fusion protein - ag1310 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Protein kinase C zeta type - BP001165-C670 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

Search more