| Gene Symbol |
MRPL41
|
| Entrez Gene |
64975
|
| Alt Symbol |
BMRP, MRP-L27, MRPL27, PIG3, RPML27
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitochondrial ribosomal protein L41
|
| Other Description |
39S ribosomal protein L27 homolog|39S ribosomal protein L41, mitochondrial|L41mt|MRP-L27 homolog|MRP-L41|bcl-2-interacting mitochondrial ribosomal protein L41|cell proliferation-inducing gene 3 protein|proliferation-inducing gene 3
|
| Swissprots |
Q96Q49 Q8IXM3
|
| Accessions |
BAB54952 EAW88399 Q8IXM3 AI091177 AY232291 AAP69986 BC040035 AAH40035 BM919526 NM_032477 NP_115866
|
| Function |
Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. {ECO:0000269|PubMed:16024796, ECO:0000269|PubMed:16256947}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:16024796}.
|
| Tissue Specificity |
Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level). {ECO:0000269|PubMed:15547950}.
|