Gene Symbol | MRPL41 |
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Entrez Gene | 64975 |
Alt Symbol | BMRP, MRP-L27, MRPL27, PIG3, RPML27 |
Species | Human |
Gene Type | protein-coding |
Description | mitochondrial ribosomal protein L41 |
Other Description | 39S ribosomal protein L27 homolog|39S ribosomal protein L41, mitochondrial|L41mt|MRP-L27 homolog|MRP-L41|bcl-2-interacting mitochondrial ribosomal protein L41|cell proliferation-inducing gene 3 protein|proliferation-inducing gene 3 |
Swissprots | Q96Q49 Q8IXM3 |
Accessions | BAB54952 EAW88399 Q8IXM3 AI091177 AY232291 AAP69986 BC040035 AAH40035 BM919526 NM_032477 NP_115866 |
Function | Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. {ECO:0000269|PubMed:16024796, ECO:0000269|PubMed:16256947}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:16024796}. |
Tissue Specificity | Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level). {ECO:0000269|PubMed:15547950}. |
MRP-L41 CRISPR/Cas9 KO Plasmid (h) - sc-413065 from Santa Cruz Biotechnology
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MRP-L41 HDR Plasmid (h) - sc-413065-HDR from Santa Cruz Biotechnology
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MRP-L41 Double Nickase Plasmid (h) - sc-413065-NIC from Santa Cruz Biotechnology
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MRP-L41 Double Nickase Plasmid (h2) - sc-413065-NIC-2 from Santa Cruz Biotechnology
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MRP-L41 CRISPR Activation Plasmid (h) - sc-413065-ACT from Santa Cruz Biotechnology
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MRP-L41 CRISPR Activation Plasmid (h2) - sc-413065-ACT-2 from Santa Cruz Biotechnology
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MRP-L41 Lentiviral Activation Particles (h) - sc-413065-LAC from Santa Cruz Biotechnology
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MRP-L41 Lentiviral Activation Particles (h2) - sc-413065-LAC-2 from Santa Cruz Biotechnology
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MRP-L41 siRNA (h) - sc-92716 from Santa Cruz Biotechnology
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MRP-L41 shRNA Plasmid (h) - sc-92716-SH from Santa Cruz Biotechnology
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MRP-L41 shRNA (h) Lentiviral Particles - sc-92716-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU057171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14575 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14575 from Sigma-Aldrich
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MRPL41 siRNA (Human) - CRJ2154 from Cohesion Biosciences
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shRNA set against Human MRPL41 (NM_032477.2) - SHH344856 from Creative biogene
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Human MRPL41 siRNA - orb272655 from Biorbyt
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MRPL41 shRNA Plasmid (Human) - CHJ2154 from Cohesion Biosciences
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MRPL41 miRNA 3'UTR clone - MiUTR3H-12150 from Creative biogene
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