Gene Symbol | GPD1L |
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Entrez Gene | 23171 |
Alt Symbol | GPD1-L |
Species | Human |
Gene Type | protein-coding |
Description | glycerol-3-phosphate dehydrogenase 1-like |
Other Description | glycerol-3-phosphate dehydrogenase 1-like protein |
Swissprots | Q14702 Q8N335 A8K9U3 Q9BRM5 |
Accessions | EAW64421 EAW64422 Q8N335 AI080105 AK074221 AK125404 BAG54194 AK292808 BAF85497 BC006168 AAH06168 BC028726 AAH28726 BX283865 D42047 BAA07648 DA318838 XM_005264983 XP_005265040 XM_006713068 XP_006713131 NM_015141 NP_055956 |
Function | Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. {ECO:0000269|PubMed:19666841, ECO:0000269|PubMed:19745168}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17967977}. Note=Localized to the region of the plasma membrane. |
Tissue Specificity | Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs. {ECO:0000269|PubMed:17967977}. |
Top Pathways | Glycerophospholipid metabolism |
GPD1L CRISPR/Cas9 KO Plasmid (h) - sc-411684 from Santa Cruz Biotechnology
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GPD1L HDR Plasmid (h) - sc-411684-HDR from Santa Cruz Biotechnology
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GPD1L Double Nickase Plasmid (h) - sc-411684-NIC from Santa Cruz Biotechnology
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GPD1L Double Nickase Plasmid (h2) - sc-411684-NIC-2 from Santa Cruz Biotechnology
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GPD1L CRISPR Activation Plasmid (h) - sc-411684-ACT from Santa Cruz Biotechnology
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GPD1L CRISPR Activation Plasmid (h2) - sc-411684-ACT-2 from Santa Cruz Biotechnology
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GPD1L Lentiviral Activation Particles (h) - sc-411684-LAC from Santa Cruz Biotechnology
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GPD1L Lentiviral Activation Particles (h2) - sc-411684-LAC-2 from Santa Cruz Biotechnology
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GPD1L siRNA (h) - sc-78210 from Santa Cruz Biotechnology
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GPD1L shRNA Plasmid (h) - sc-78210-SH from Santa Cruz Biotechnology
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GPD1L shRNA (h) Lentiviral Particles - sc-78210-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU013581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9522 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9522 from Sigma-Aldrich
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GPD1L siRNA (Human) - CRH8054 from Cohesion Biosciences
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GPD1L - MBS8231125 from MyBioSource
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Human GPD1L siRNA - orb268556 from Biorbyt
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GPD1L shRNA Plasmid (Human) - CHH8054 from Cohesion Biosciences
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