| Gene Symbol |
CCKAR
|
| Entrez Gene |
886
|
| Alt Symbol |
CCK-A, CCK1-R, CCK1R, CCKRA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cholecystokinin A receptor
|
| Other Description |
CCK-A receptor|CCK-AR|cholecystokinin receptor type A|cholecystokinin type-A receptor|cholecystokinin-1 receptor
|
| Swissprots |
B2R9Z5 P32238
|
| Accessions |
AAA91123 BAA90879 EAW92850 P32238 AK313978 BAG36692 AY322549 AAP84362 BC074987 AAH74987 L13605 AAA35659 L19315 AAA02819 NM_000730 NP_000721
|
| Function |
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Top Pathways |
Calcium signaling pathway, Pancreatic secretion, Neuroactive ligand-receptor interaction
|
![Western Blot: CCKAR Overexpression Lysate (Adult Normal) [NBL1-08839] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CCKAR.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8903_CCKAR%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08839-img0002.jpg)