Gene Symbol | CCKAR |
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Entrez Gene | 886 |
Alt Symbol | CCK-A, CCK1-R, CCK1R, CCKRA |
Species | Human |
Gene Type | protein-coding |
Description | cholecystokinin A receptor |
Other Description | CCK-A receptor|CCK-AR|cholecystokinin receptor type A|cholecystokinin type-A receptor|cholecystokinin-1 receptor |
Swissprots | B2R9Z5 P32238 |
Accessions | AAA91123 BAA90879 EAW92850 P32238 AK313978 BAG36692 AY322549 AAP84362 BC074987 AAH74987 L13605 AAA35659 L19315 AAA02819 NM_000730 NP_000721 |
Function | Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Top Pathways | Calcium signaling pathway, Pancreatic secretion, Neuroactive ligand-receptor interaction |
CCK-AR CRISPR/Cas9 KO Plasmid (h) - sc-402419 from Santa Cruz Biotechnology
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CCK-AR HDR Plasmid (h) - sc-402419-HDR from Santa Cruz Biotechnology
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CCK-AR Double Nickase Plasmid (h) - sc-402419-NIC from Santa Cruz Biotechnology
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CCK-AR Double Nickase Plasmid (h2) - sc-402419-NIC-2 from Santa Cruz Biotechnology
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CCK-AR CRISPR Activation Plasmid (h) - sc-402419-ACT from Santa Cruz Biotechnology
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CCK-AR CRISPR Activation Plasmid (h2) - sc-402419-ACT-2 from Santa Cruz Biotechnology
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CCK-AR Lentiviral Activation Particles (h) - sc-402419-LAC from Santa Cruz Biotechnology
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CCK-AR Lentiviral Activation Particles (h2) - sc-402419-LAC-2 from Santa Cruz Biotechnology
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CCK-AR siRNA (h) - sc-43670 from Santa Cruz Biotechnology
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CCK-AR shRNA Plasmid (h) - sc-43670-SH from Santa Cruz Biotechnology
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CCK-AR shRNA (h) Lentiviral Particles - sc-43670-V from Santa Cruz Biotechnology
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CCK-A R RNAi - H00000886-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN1790 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1790 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01363 from Sigma-Aldrich
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CCKAR siRNA (Human) - CRH0622 from Cohesion Biosciences
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CCKAR - MBS8201259 from MyBioSource
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shRNA set against Human CCKAR (NM_000730.2) - SHH257449 from Creative biogene
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shRNA set against Human CCKAR(NM_000730.2) - SHG134261 from Creative biogene
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Human CCKAR siRNA - orb261124 from Biorbyt
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CCKAR shRNA Plasmid (Human) - CHH0622 from Cohesion Biosciences
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CCKAR miRNA 3'UTR clone - MiUTR1H-01788 from Creative biogene
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