| Gene Symbol |
Mgmt
|
| Entrez Gene |
17314
|
| Alt Symbol |
AGT, AI267024, Agat
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
O-6-methylguanine-DNA methyltransferase
|
| Other Description |
6-O-methylguanine-DNA methyltransferase|O-6-alkylguanine-DNA alkyltransferase|O-6-methylguanine-DNA-alkyltransferase|methylated-DNA--protein-cysteine methyltransferase
|
| Swissprots |
P26187 Q54A49
|
| Accessions |
EDL17816 EDL17817 EDL17818 P26187 AB092489 BAC16763 AB092490 BAC16764 AK090389 BC031888 AAH31888 BC096557 AAH96557 BY344992 M84524 AAA37126 XM_006507405 XP_006507468 XM_006507406 XP_006507469 XM_006507407 XP_006507470 XM_006507408 XP_006507471 XM_006507409 XP_006507472 XM_006507410 XP_006507473 NM_008598 NP_032624
|
| Function |
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|