Gene Symbol | Mgmt |
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Entrez Gene | 17314 |
Alt Symbol | AGT, AI267024, Agat |
Species | Mouse |
Gene Type | protein-coding |
Description | O-6-methylguanine-DNA methyltransferase |
Other Description | 6-O-methylguanine-DNA methyltransferase|O-6-alkylguanine-DNA alkyltransferase|O-6-methylguanine-DNA-alkyltransferase|methylated-DNA--protein-cysteine methyltransferase |
Swissprots | P26187 Q54A49 |
Accessions | EDL17816 EDL17817 EDL17818 P26187 AB092489 BAC16763 AB092490 BAC16764 AK090389 BC031888 AAH31888 BC096557 AAH96557 BY344992 M84524 AAA37126 XM_006507405 XP_006507468 XM_006507406 XP_006507469 XM_006507407 XP_006507470 XM_006507408 XP_006507471 XM_006507409 XP_006507472 XM_006507410 XP_006507473 NM_008598 NP_032624 |
Function | Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. |
Subcellular Location | Nucleus {ECO:0000305}. |
MGMT CRISPR/Cas9 KO Plasmid (m) - sc-421647 from Santa Cruz Biotechnology
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MGMT HDR Plasmid (m) - sc-421647-HDR from Santa Cruz Biotechnology
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MGMT Double Nickase Plasmid (m) - sc-421647-NIC from Santa Cruz Biotechnology
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MGMT Double Nickase Plasmid (m2) - sc-421647-NIC-2 from Santa Cruz Biotechnology
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MGMT CRISPR Activation Plasmid (m) - sc-421647-ACT from Santa Cruz Biotechnology
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MGMT CRISPR Activation Plasmid (m2) - sc-421647-ACT-2 from Santa Cruz Biotechnology
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MGMT Lentiviral Activation Particles (m) - sc-421647-LAC from Santa Cruz Biotechnology
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MGMT Lentiviral Activation Particles (m2) - sc-421647-LAC-2 from Santa Cruz Biotechnology
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MGMT siRNA (m) - sc-35928 from Santa Cruz Biotechnology
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MGMT shRNA Plasmid (m) - sc-35928-SH from Santa Cruz Biotechnology
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MGMT shRNA (m) Lentiviral Particles - sc-35928-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU041001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN35550 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35550 from Sigma-Aldrich
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MGMT siRNA (Mouse) - CRM2536 from Cohesion Biosciences
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shRNA set against Mouse Mgmt(NM_008598.2) - SHG046073 from Creative biogene
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Mouse MGMT siRNA - orb282012 from Biorbyt
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MGMT shRNA Plasmid (Mouse) - CHM2536 from Cohesion Biosciences
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MGMT miRNA 3'UTR clone - MiUTR1M-07102 from Creative biogene
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