| Gene Symbol |
GLCE
|
| Entrez Gene |
26035
|
| Alt Symbol |
HSEPI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glucuronic acid epimerase
|
| Other Description |
D-glucuronyl C5-epimerase|UDP-glucuronic acid epimerase|glucuronyl C5-epimerase|heparan sulfate C5-epimerase|heparan sulfate epimerase|heparin/heparan sulfate-glucuronic acid C5-epimerase|heparin/heparan sulfate:glucuronic acid C5-epimerase|heparosan-N-sulfate-glucuronate 5-epimerase
|
| Swissprots |
O94923 Q6GUQ2
|
| Accessions |
EAW77837 O94923 AA393928 AB020643 BAA74859 AK002188 BAG51026 AY635582 AAT48654 BC026096 BC160046 AAI60046 N41364 W87397 XM_005254298 XP_005254355 XM_005254299 XP_005254356 NM_015554 NP_056369
|
| Function |
Converts D-glucuronic acid residues adjacent to N- sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. {ECO:0000269|PubMed:20118238}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|