Gene Symbol | GLCE |
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Entrez Gene | 26035 |
Alt Symbol | HSEPI |
Species | Human |
Gene Type | protein-coding |
Description | glucuronic acid epimerase |
Other Description | D-glucuronyl C5-epimerase|UDP-glucuronic acid epimerase|glucuronyl C5-epimerase|heparan sulfate C5-epimerase|heparan sulfate epimerase|heparin/heparan sulfate-glucuronic acid C5-epimerase|heparin/heparan sulfate:glucuronic acid C5-epimerase|heparosan-N-sulfate-glucuronate 5-epimerase |
Swissprots | O94923 Q6GUQ2 |
Accessions | EAW77837 O94923 AA393928 AB020643 BAA74859 AK002188 BAG51026 AY635582 AAT48654 BC026096 BC160046 AAI60046 N41364 W87397 XM_005254298 XP_005254355 XM_005254299 XP_005254356 NM_015554 NP_056369 |
Function | Converts D-glucuronic acid residues adjacent to N- sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. {ECO:0000269|PubMed:20118238}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
GLCE CRISPR/Cas9 KO Plasmid (h) - sc-407179 from Santa Cruz Biotechnology
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GLCE HDR Plasmid (h) - sc-407179-HDR from Santa Cruz Biotechnology
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GLCE Double Nickase Plasmid (h) - sc-407179-NIC from Santa Cruz Biotechnology
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GLCE Double Nickase Plasmid (h2) - sc-407179-NIC-2 from Santa Cruz Biotechnology
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GLCE CRISPR Activation Plasmid (h) - sc-407179-ACT from Santa Cruz Biotechnology
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GLCE CRISPR Activation Plasmid (h2) - sc-407179-ACT-2 from Santa Cruz Biotechnology
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GLCE Lentiviral Activation Particles (h) - sc-407179-LAC from Santa Cruz Biotechnology
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GLCE Lentiviral Activation Particles (h2) - sc-407179-LAC-2 from Santa Cruz Biotechnology
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GLCE siRNA (h) - sc-90153 from Santa Cruz Biotechnology
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GLCE shRNA Plasmid (h) - sc-90153-SH from Santa Cruz Biotechnology
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GLCE shRNA (h) Lentiviral Particles - sc-90153-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU149821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9334 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9334 from Sigma-Aldrich
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GLCE siRNA (Human) - CRH8668 from Cohesion Biosciences
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GLCE - MBS8235102 from MyBioSource
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shRNA set against Human Glce (NM_015554.1) - SHH301678 from Creative biogene
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shRNA set against Human GLCE(NM_015554.1) - SHH086627 from Creative biogene
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GLCE shRNA Plasmid (Human) - CHH8668 from Cohesion Biosciences
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GLCE miRNA 3'UTR clone - MiUTR1H-04057 from Creative biogene
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