ITGAM

Gene Symbol	ITGAM
Entrez Gene	3684
Alt Symbol	CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6
Species	Human
Gene Type	protein-coding
Description	integrin, alpha M (complement component 3 receptor 3 subunit)
Other Description	CD11 antigen-like family member B|CR-3 alpha chain|antigen CD11b (p170)|cell surface glycoprotein MAC-1 subunit alpha|integrin alpha-M|leukocyte adhesion receptor MO1|macrophage antigen alpha polypeptide|neutrophil adherence receptor alpha-M subunit
Swissprots	Q4VAK0 P11215 Q4VAK2 Q4VAK1
Accessions	AAA51960 AAA58410 AAB24821 CCF76944 EAW52143 EAW52144 P11215 AA436312 AK057856 AK127637 BAG54538 AY187247 AY187248 BC096346 AAH96346 BC096347 AAH96347 BC096348 AAH96348 BC099660 AAH99660 BM194233 J03925 AAA59544 J04145 AAA59903 M18044 AAA59491 XM_006721045 XP_006721108 XM_011545850 XP_011544152 XM_011545851 XP_011544153 XR_950796 NM_000632 NP_000623 NM_001145808 NP_001139280
Function	Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Predominantly expressed in monocytes and granulocytes.
Top Pathways	Staphylococcus aureus infection, Legionellosis, Tuberculosis, Rap1 signaling pathway, Pertussis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD11b protein fragment - ab126010 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

ITGAM / CD11b Antibody Blocking Peptide - LS-E390 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ITGAM / CD11b Antibody Blocking Peptide - LS-E26359 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD11b/c Blocking Peptide - NB110-40766PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg

Recombinant Human CD11b Protein - H00003684-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CD11b-Antibody-N-term-Blocking-peptide - BP10668a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ITGAM blocking peptide - GTX89035-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human Integrin alpha M beta 2, CF - 4047-AM-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

CD11b Protein (OPPA01374) - OPPA01374 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

Human SVIP protein - orb81000 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human Integrin Alpha M Protein - abx067281 from Abbexa Category Protein Source E.coli Species Human

CD11b Peptide - AC21-1194-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CD11b - H00003684-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD11b - H00003684-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Integrin Alpha M (ITGaM), Human - 20-7923 from ARP American Research Products Category Protein Prices $489.00 Sizes 50 µg Source E.coli Species Human

ITGAM Peptide - 45-783P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

CD11B fusion protein - ag16327 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CD11B fusion protein - Ag16714 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human CD11b - BP000307-PRO-472 from Syd Labs Category Protein Prices $175.00, $270.00, $490.00 Sizes 2 µg, 5 µg, 10 µg Source E.coli-derived. Species Human

CD11b Human - GWB-E9A388 from Genway Biotech Category Protein Prices $245.00, $375.00, $665.00 Sizes 2 μg, 5 μg, 10 μg Species Human

CD11b - GWB-E81272 from Genway Biotech Category Protein Prices $438.00 Sizes 10 µg

Recombinant Human ITGAM, flag & His tagged - ITGAM-4117H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human ITGAM, GST-tagged - ITGAM-231H from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human ITGAM&ITGB2 - ITGAM&ITGB2-692H from Creative Biomart Category Protein Source CHO cells Species Human

Recombinant Human Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit) - ITGAM-4257H from Creative Biomart Category Protein Source Human

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