Gene Symbol |
HAVCR2
|
Entrez Gene |
84868
|
Alt Symbol |
HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
hepatitis A virus cellular receptor 2
|
Other Description |
T cell immunoglobulin mucin 3|T cell immunoglobulin mucin-3|T-cell immunoglobulin and mucin domain-containing protein 3|T-cell immunoglobulin mucin family member 3|T-cell immunoglobulin mucin receptor 3|T-cell membrane protein 3|kidney injury molecule-3
|
Swissprots |
Q96K94 Q8WW60 Q8TDQ0 B2RAY2
|
Accessions |
CAH05307 EAW61613 EAW61614 Q8TDQ0 AB924452 BAQ00263 AF251707 AAM19100 AF450242 AAL65157 AF450243 AAL65158 AK027334 BAB55044 AK130144 AK314406 BAG37029 AY069944 AAL55401 BC020843 AAH20843 BC063431 AAH63431 BP291914 HQ448118 ADQ32599 JX049979 AFO66593 NM_032782 NP_116171
|
Function |
Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. {ECO:0000269|PubMed:14556005, ECO:0000269|PubMed:16286920}.
|
Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
Tissue Specificity |
T-helper type 1 lymphocyte (Th1)-specific.
|