Gene Symbol | HAVCR2 |
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Entrez Gene | 84868 |
Alt Symbol | HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3 |
Species | Human |
Gene Type | protein-coding |
Description | hepatitis A virus cellular receptor 2 |
Other Description | T cell immunoglobulin mucin 3|T cell immunoglobulin mucin-3|T-cell immunoglobulin and mucin domain-containing protein 3|T-cell immunoglobulin mucin family member 3|T-cell immunoglobulin mucin receptor 3|T-cell membrane protein 3|kidney injury molecule-3 |
Swissprots | Q96K94 Q8WW60 Q8TDQ0 B2RAY2 |
Accessions | CAH05307 EAW61613 EAW61614 Q8TDQ0 AB924452 BAQ00263 AF251707 AAM19100 AF450242 AAL65157 AF450243 AAL65158 AK027334 BAB55044 AK130144 AK314406 BAG37029 AY069944 AAL55401 BC020843 AAH20843 BC063431 AAH63431 BP291914 HQ448118 ADQ32599 JX049979 AFO66593 NM_032782 NP_116171 |
Function | Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. {ECO:0000269|PubMed:14556005, ECO:0000269|PubMed:16286920}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | T-helper type 1 lymphocyte (Th1)-specific. |
Active human TIM 3 full length protein - ab155742 from Abcam
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Human TIM 3 full length protein - ab131843 from Abcam
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Human TIM 3 peptide - ab48044 from Abcam
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Human TIM 3 protein fragment - ab139246 from Abcam
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Human TIM 3 protein fragment - ab151635 from Abcam
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Human TIM 3 protein fragment - ab182714 from Abcam
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Human TIM 3 protein fragment - ab198481 from Abcam
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HAVCR2 / TIM-3 Antibody Blocking Peptide - LS-E26036 from LifeSpan Bioscience
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HAVCR2 / TIM-3 Antibody Blocking Peptide - LS-E16633 from LifeSpan Bioscience
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Recombinant Human TIM-3 Protein - H00084868-P01 from Novus Biologicals
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Recombinant Human TIM-3 Protein - NBP2-23118 from Novus Biologicals
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TIM-3 blocking peptide - GTX89379-PEP from GeneTex
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Recombinant Human TIM-3 Fc Chimera, CF - 2365-TM-050 from R&D Systems
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Recombinant Cynomolgus Monkey TIM-3 Fc Chimera, CF - 7914-TM-050 from R&D Systems
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HAVCR2 Protein Lysate (APL10445) - APL10445 from Aviva Systems Biology
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HAVCR2 Protein Lysate (APL10721) - APL10721 from Aviva Systems Biology
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Recombinant human Hepatitis A virus cellular receptor 2 (OPCA00111) - OPCA00111 from Aviva Systems Biology
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Recombinant human Hepatitis A virus cellular receptor 2 (OPCA01244) - OPCA01244 from Aviva Systems Biology
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Human TIM3 His tag protein - orb83868 from Biorbyt
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Cynomolgus TIM3 protein - orb139749 from Biorbyt
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Human HAVCR2 protein - orb168466 from Biorbyt
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Human HAVCR2 protein - orb244262 from Biorbyt
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Human TIM3 Fc His tag protein - orb83131 from Biorbyt
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Human HAVCR2 protein - orb245860 from Biorbyt
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Human TIM-3 R protein - orb163346 from Biorbyt
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